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Invitrogen
CDC25A Polyclonal Antibody
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Product Details
PA5-99521
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDC25A(Accession P30304), corresponding to amino acid residues D50-N100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2818454
Product Specific Information
Antibody detects endogenous levels of total CDC25A.
Target Information
CDC25a is a member of the CDC25 family of phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. CDC25a is required for progression through G1 and S phases of the cell cycle. CDC25a activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC25 isoform A1-CAG; CDC25A2-CAG isoform; Dual specificity phosphatase Cdc25A; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1
Gene Aliases: CDC25A; CDC25A2; Cdc25m3; D9Ertd393e
UniProt ID: (Human) P30304, (Rat) P48965, (Mouse) P48964
Entrez Gene ID: (Human) 993, (Rat) 171102, (Mouse) 12530
G1/S transition of mitotic cell cycle
mitotic nuclear division
response to radiation
cellular response to UV
peptidyl-tyrosine dephosphorylation
cell division
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
DNA replication
cell proliferation
regulation of cell cycle
mitotic M phase
protein dephosphorylation
cell cycle
dephosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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