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Invitrogen
CDC37 Recombinant Rabbit Monoclonal Antibody (6X0A3)
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FIGURE: 1 / 1
CDC37 Antibody (MA5-35538) in WB
Western blot analysis of CDC37 in extracts of various cell lines. Samples were incubated with CDC37 Monoclonal antibody (Product # MA5-35538) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
MA5-35538
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6X0A3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDC37 (Q16543)
Conjugate
Form
Liquid
Concentration
0.12 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849438
Product Specific Information
Immunogen sequence: MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ
Target Information
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC 37; CDC37 (cell division cycle 37 S. cerevisiae homolog); CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog; Cdc37 homolog; CDC37 protein; cell division cycle 37 homolog; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37; p50Cdc37
Gene Aliases: CDC37; CDC37A; p50; P50CDC37
UniProt ID: (Human) Q16543, (Rat) Q63692, (Mouse) Q61081
Entrez Gene ID: (Human) 11140, (Rat) 114562, (Mouse) 12539
protein tyrosine kinase activity
protein binding
protein kinase regulator activity
kinase binding
protein kinase binding
heat shock protein binding
unfolded protein binding
chaperone binding
Hsp90 protein binding
protein C-terminus binding
mitogen-activated protein kinase kinase kinase binding
protein kinase B binding
protein folding
protein stabilization
regulation of cell cycle
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
regulation of cyclin-dependent protein serine/threonine kinase activity
protein targeting
posttranscriptional regulation of gene expression
peptidyl-tyrosine phosphorylation
ERBB2 signaling pathway
mitophagy in response to mitochondrial depolarization
regulation of protein kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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