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Product Details
H00010435-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2H7
Immunogen
CDC42EP2 (NP_006770, 102 a.a. approximately 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: PLLKNAISLP VIGGPQALTL PTAQAPPKPP RLHLETPQPS PQEGGSVDIW RIPETGSPNS GLTPESGAEE PFLSNASSLL SLHVDLGPSI LDDVLQIMDQ DLDSMQIPT
Target Information
Cdc42, a small GTPase, regulates Actin polymerization, elongation of cell shape and cell signaling through interactions with many different downstream effector proteins, most of which contain a Cdc42-binding motif known as a CRIB domain. Cdc42EP2 (Cdc42 effector protein 2), also known as BORG1 or CEP2, is a 210 amino acid intracytoplasmic protein that localizes to both the cytoplasm and the cytoskeleton and contains one CRIB domain. Highly expressed in heart and present at lower levels in liver and pancreas, Cdc42EP2 interacts with Cdc42 and is thought to be involved in the organization of the Actin cytoskeleton and may also influence Actin filament assembly and overall cell shape.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Binder of Rho GTPases 1; CDC42 effector protein (Rho GTPase binding) 2; Cdc42 effector protein 2; CRIB-containing BOGR1 protein
Gene Aliases: BORG1; CDC42EP2; CEP2
UniProt ID: (Human) O14613
Entrez Gene ID: (Human) 10435
actin filament organization
Rho protein signal transduction
regulation of cell shape
actin cytoskeleton organization
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
positive regulation of protein complex assembly
positive regulation of GTPase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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