Proteintech

CDC5L Polyclonal Antibody

CDC5L Antibody in Immunocytochemistry (ICC/IF)

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CDC5L Antibody (12974-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 12974-1-AP (CDC5L antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CDC5L Antibody in Immunoprecipitation (IP)

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Product Details

12974-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDC5L Fusion Protein Ag3578 (451-803 aa encoded by BC001568)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NPEDGMADY SDPSYVKQME RESREHLRLG LLGLPAPKND FEIVLPENAE KELEEREIDD TYIEDAADVD ARKQAIRDAE RVKEMKRMHK AVQKDLPRPS EVNETILRPL NVEPPLTDLQ KSEELIKKEM ITMLHYDLLH HPYEPSGNKK GKTVGFGTNN SEHITYLEHN PYEKFSKEEL KKAQDVLVQE MEVVKQGMSH GELSSEAYNQ VWEECYSQVL YLPGQSRYTR ANLASKKDRI ESLEKRLEIN RGHMTTEAKR AAKMEKKMKI LLGGYQSRAM GLMKQLNDLW DQIEQAHLEL RTFEELKKHE DSAIPRRLEC LKEDVQRQQE REKELQHRYA DLLLEKETLK SKF (451-803 aa encoded by BC001568)

Target Information

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway.

Cancer medicine

Zhang C,Li Y,Zhao W,Liu G,Yang Q

Fri May 01 00:00:00 UTC 2020

O-GlcNAcylation of Thr¹²/Ser⁵⁶ in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.

The Journal of biological chemistry

Liu L,Li L,Ma C,Shi Y,Liu C,Xiao Z,Zhang Y,Tian F,Gao Y,Zhang J,Ying W,Wang PG,Zhang L

Fri Nov 08 00:00:00 UTC 2019

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 UTC 2017

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Oncotarget

Gu Z,Zhang H,Li Y,Shen S,Yin X,Zhang W,Cheng R,Zhang Y,Zhang X,Chen H,Huang B,Cao Y

Tue Dec 26 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: CDC5 cell division cycle 5-like; Cdc5-like protein; Cdc5-related protein; Cell division cycle 5-like protein; cell division cycle 5-related protein; dJ319D22.1 (CDC5-like protein); hCDC5; Pombe Cdc5-related protein

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Gene Aliases: 1200002I02Rik; AA408004; CDC5; CDC5-LIKE; CDC5L; CEF1; dJ319D22.1; KIAA0432; PCDC5RP

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UniProt ID: (Human) Q99459, (Rat) O08837, (Mouse) Q6A068

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Entrez Gene ID: (Human) 988, (Rat) 85434, (Mouse) 71702

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Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor recruiting transcription corepressor binding DNA binding protein binding protein phosphatase 1 binding protein kinase binding leucine zipper domain binding sequence-specific DNA binding transcription regulatory region DNA binding poly(A) RNA binding WD40-repeat domain binding chromatin binding protein domain specific binding RNA binding

Process(es)

G2/M transition of mitotic cell cycle DNA repair transcription, DNA-templated regulation of transcription, DNA-templated mRNA processing RNA splicing signal transduction involved in DNA damage checkpoint mitotic cell cycle mRNA splicing, via spliceosome regulation of transcription from RNA polymerase II promoter cell differentiation cellular response to fibroblast growth factor stimulus cellular response to interleukin-2 cellular response to wortmannin cellular response to nerve growth factor stimulus cellular response to prolactin cellular response to DNA damage stimulus cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDC5L Polyclonal Antibody

CDC5L Antibody (12974-1-AP) in ICC/IF

Product Details

12974-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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