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Product Details
PA5-101054
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CDC7(Accession O00311), corresponding to amino acid residues F15-G65.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2850499
Product Specific Information
Antibody detects endogenous levels of total CDC7.
Target Information
CDC7 is a cell division cycle 7 homolog protein that is critical for the G1/S transition and is also essential for initiation of DNA replication as cell division occurs. CDC7 is expressed in many normal tissues, but the overexpression of CDC7 may be associated with neoplastic transformation for some tumors and transformed cell lines. CDC7/DBF4 kinase promotes S phase by alleviating an inhibitory activity in Mcm4 that evolved to integrate several protein kinase. CDC7 encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1; Cdc7 Kinase; CDC7-like 1; CDC7-related kinase; cell division cycle 7 homolog; cell division cycle 7-like 1; cell division cycle 7-like protein 1; Cell division cycle 7-related protein kinase; MGC117361; MGC126237; MGC126238; MGC91067
Gene Aliases: AI597260; CDC7; CDC7L1; HsCDC7; Hsk1; huCDC7; muCdc7
UniProt ID: (Human) O00311, (Mouse) Q9Z0H0
Entrez Gene ID: (Human) 8317, (Mouse) 12545
double-strand break repair via break-induced replication
DNA replication initiation
protein phosphorylation
phagocytosis
cell cycle
positive regulation of cell proliferation
regulation of cell shape
positive regulation of nuclear cell cycle DNA replication
positive regulation of G2/M transition of mitotic cell cycle
phosphorylation
peptidyl-serine phosphorylation
cell cycle phase transition
cell division
G1/S transition of mitotic cell cycle
DNA replication
Performance Guarantee
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