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Invitrogen
CDH4 Polyclonal Antibody
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FIGURE: 1 / 1
CDH4 Antibody (PA5-78376) in IHC (P)
R-cadherin antibody detects R-cadherin protein at membrane on mouse duodenum by immunohistochemical analysis. Sample: Paraffin-embedded mouse duodenum. R-cadherin antibody (Product # PA5-78376) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-78376
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human R-Cadherin. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735622
Product Specific Information
Predicted Reactivity: Human (100%), Chicken (91%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CDH4 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin; cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); Cadherin-4; R-CAD; R-cadherin; retina cadherin; Retinal cadherin
Gene Aliases: AW120700; CAD4; CDH4; R-CAD; R-Cadh; R-cadherin; RCAD
UniProt ID: (Human) P55283, (Mouse) P39038
Entrez Gene ID: (Human) 1002, (Mouse) 12561
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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