Proteintech

CDH5 Monoclonal Antibody (4F9B10)

2 Published Figures

18 References

View all (56) VE-cadherin (CD144) antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (7)
Published Figures (2)

CDH5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

CDH5 Antibody (66804-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 66804-1-IG (CDH5 antibody) at dilution of 1:400 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Product Image Gallery

Product Details

66804-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:3,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:400

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Not applicable (N/A)

View 7 publications 7 publications

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4F9B10

Immunogen

CDH5 Fusion Protein Ag27501 (54-241 aa encoded by NM_001795)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MHIDEEKNT SLPHHVGKIK SSVSRKNAKY LLKGEYVGKV FRVDAETGDV FAIERLDREN ISEYHLTAVI VDKDTGENLE TPSSFTIKVH DVNDNWPVFT HRLFNASVPE SSAVGTSVIS VTAVDADDPT VGDHASVMYQ ILKGKEYFAI DNSGRIITIT KSLDREKQAR YEIVVEARDA QGLRGDSGT (54-241 aa encoded by NM_001795 )

Target Information

VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.

Journal of cellular and molecular medicine

Li L,Cao X,Huang L,Huang X,Gu J,Yu X,Zhu Y,Zhou Y,Song Y,Zhu M

Mon May 01 00:00:00 UTC 2023

Influence of lung cancer model characteristics on tumor targeting behavior of nanodrugs.

Journal of controlled release : official journal of the Controlled Release Society

Xu W,Yang S,Lu L,Xu Q,Wu S,Zhou J,Lu J,Fan X,Meng N,Ding Y,Zheng X,Lu W

Wed Feb 01 00:00:00 UTC 2023

Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Tang BL,Liu Y,Zhang JL,Lu ML,Wang HX

Tue Aug 01 00:00:00 UTC 2023

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Journal of ethnopharmacology

Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL

Sat Oct 28 00:00:00 UTC 2023

Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.

Journal of ethnopharmacology

Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL

Sat Oct 28 00:00:00 UTC 2023

Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X.

Cancer gene therapy

Zhang X,Han J,Fan D,Wang J,Lin X,Zhang H,Zhang C,Bai J,Huang H,Gu Y

Sun Jan 01 00:00:00 UTC 2023

Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model.

Biosensors

Wang P,Wu Y,Chen W,Zhang M,Qin J

Mon Jan 31 00:00:00 UTC 2022

Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model.

Biosensors

Wang P,Wu Y,Chen W,Zhang M,Qin J

Mon Jan 31 00:00:00 UTC 2022

Naringin suppressed airway inflammation and ameliorated pulmonary endothelial hyperpermeability by upregulating Aquaporin1 in lipopolysaccharide/cigarette smoke-induced mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang HH,Zhou XJ,Zhong YS,Ji LT,Yu WY,Fang J,Ying HZ,Li CY

Wed Jun 01 00:00:00 UTC 2022

Prrx1 promotes resistance to temozolomide by upregulating ABCC1 and inducing vasculogenic mimicry in glioma.

American journal of cancer research

Chen Z,Zhang Y,Chen Y,Lin W,Zhang Y,Cai G,Sun X,Zheng K,He J,Ai T,Wang J,Zhao L,Ke Y

Tue Sep 20 00:00:00 UTC 2022

制备人脐静脉内皮细胞和人肺腺癌细胞融合细胞的新方法.

Technology in cancer research & treatment

席玉

Published figure using CDH5 monoclonal antibody (Product # 66804-1-IG) in Western Blot

Thu Feb 10 00:00:00 UTC 2022

Heteronemin Suppresses Lymphangiogenesis through ARF-1 and MMP-9/VE-Cadherin/Vimentin.

Biomedicines

Chen HL,Su YC,Chen HC,Su JH,Wu CY,Wang SW,Lin IP,Chen CY,Lee CH

Sun Aug 29 00:00:00 UTC 2021

Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang M,Wang P,Luo R,Wang Y,Li Z,Guo Y,Yao Y,Li M,Tao T,Chen W,Han J,Liu H,Cui K,Zhang X,Zheng Y,Qin J

Mon Feb 01 00:00:00 UTC 2021

A reciprocal feedback of miR-548ac/YB-1/Snail induces EndMT of HUVECs during acidity microenvironment.

Cancer cell international

Chen J,Han S,Chen J,Hu P,Zeng Z,Hu Y,Xiong H,Ke Z,Zhang Y,Xu F,Zhao G

Mon Dec 20 00:00:00 UTC 2021

A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.

Cell death & disease

Wang P,Luo R,Zhang M,Wang Y,Song T,Tao T,Li Z,Jin L,Zheng H,Chen W,Zhao M,Zheng Y,Qin J

Tue Dec 08 00:00:00 UTC 2020

2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ) inhibits cancer cell metastasis behavior of TNBC via suppressing EMT and VEGF.

Chemico-biological interactions

Zheng D,Wu Z,Han J,Guan Q,Li Z,Zuo D,Zhang W,Wu Y

Fri Sep 25 00:00:00 UTC 2020

LncRNA Gm16410 regulates PM_2.5-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.

Ecotoxicology and environmental safety

Ma K,Li C,Xu J,Ren F,Xu X,Liu C,Niu B,Li F

Tue Dec 01 00:00:00 UTC 2020

Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.

Cell proliferation

Wang HF,Wang SS,Zheng M,Dai LL,Wang K,Gao XL,Cao MX,Yu XH,Pang X,Zhang M,Wu JB,Wu JS,Yang X,Tang YJ,Chen Y,Tang YL,Liang XH

Wed May 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; endothelial-specific cadherin; Vascular endothelial cadherin; VE-cadherin

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Gene Aliases: 7B4; CD144; CDH5

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UniProt ID: (Human) P33151

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Entrez Gene ID: (Human) 1003

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Function(s)

receptor binding calcium ion binding protein binding beta-catenin binding protein phosphatase binding ion channel binding

Process(es)

blood vessel maturation cell-cell junction assembly homophilic cell adhesion via plasma membrane adhesion molecules transforming growth factor beta receptor signaling pathway negative regulation of cell proliferation single organismal cell-cell adhesion adherens junction organization positive regulation of establishment of endothelial barrier regulation of establishment of cell polarity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDH5 Monoclonal Antibody (4F9B10)

CDH5 Antibody (66804-1-IG) in IHC (P)

Product Details

66804-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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