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NeoBiotechnologies
CDK4 Recombinant Rabbit Monoclonal Antibody (CDK4/8351R)
Product Details
1019-RBM3-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
CDK4/8351R
Immunogen
Recombinant fragment corresponding to N-terminal of human CDK4 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: cervical carcinoma and liposarcomas. Human urothelial carcinoma
Cellular Location: Nucleus. Cytoplasm.
Target Information
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cell division protein kinase 4; Cyclin-dependent kinase 4; MGC14458; PSK-J3
Gene Aliases: CDK4; CMM3; PSK-J3
UniProt ID: (Human) P11802
Entrez Gene ID: (Human) 1019
G1/S transition of mitotic cell cycle
lens development in camera-type eye
protein phosphorylation
signal transduction
circadian rhythm
positive regulation of cell proliferation
response to toxic substance
response to lead ion
regulation of gene expression
positive regulation of G2/M transition of mitotic cell cycle
organ regeneration
response to testosterone
response to drug
positive regulation of apoptotic process
positive regulation of translation
positive regulation of cell cycle
positive regulation of cell size
regulation of protein kinase activity
positive regulation of fibroblast proliferation
cell division
response to hyperoxia
negative regulation of cell cycle arrest
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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