Invitrogen

CDK7 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-95135

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cdk7 (329-346aa RKRAEALEQGILPKKLIF).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806940

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Testis Tissue, Rat Ovary Tissue, HELA whole cell, MCF-7 whole cell, A549 whole cell, COLO320 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

The trimeric complex of CDK7, cyclin H and MNAT1, functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This complex is thought to serve as a direct link between the regulation of transcription and the cell cycle. The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). CDK7 may be a target of germline cancer-inducing mutations.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 39 KDa protein kinase; 39 protein kinase; CAK; CDK; CDK-activating kinase; CDK-activating kinase 1; Cell division protein kinase 7; CR4 protein kinase; CRK4; CRK4 PK (CDC2-related-kinase-4 protein kinase); Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; OTTHUMP00000222032; OTTHUMP00000222033; P39 Mo15; Protein-tyrosine kinase MPK-7; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit

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Gene Aliases: AI323415; AI528512; C230069N13; CAK; CAK1; CDK7; CDKN7; Crk4; HCAK; MO15; Mpk-7; p39MO15; STK1

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UniProt ID: (Human) P50613, (Mouse) Q03147

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Entrez Gene ID: (Human) 1022, (Rat) 171150, (Mouse) 12572

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Function(s)
transcription coactivator activity protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding protein C-terminus binding DNA-dependent ATPase activity RNA polymerase II carboxy-terminal domain kinase activity kinase activity androgen receptor binding protein complex binding nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
DNA repair regulation of transcription, DNA-templated transcription from RNA polymerase II promoter protein phosphorylation positive regulation of transcription from RNA polymerase II promoter cell division meiotic cell cycle regulation of cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle transcription-coupled nucleotide-excision repair nucleotide-excision repair, preincision complex assembly transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping cell cycle arrest cell proliferation androgen receptor signaling pathway snRNA transcription from RNA polymerase II promoter positive regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus cell cycle phosphorylation
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