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Invitrogen
CELSR1 Polyclonal Antibody
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Product Details
PA5-111365
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human CELSR1. Recombinant protein control fragment (Product #RP-104236).
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856775
Product Specific Information
Immunogen sequence: PTSFRLQILN NYLQFEVSHG PSDVESVMLS GLRVTDGEWH HLLIELKNVK EDSEMKHLVT MTLDYGMDQN KADIGGMLPG LTVRSVVV
Target Information
CELSR1 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor like repeats and two laminin A G type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact mediated communication, with cadherin domains acting as homophilic binding regions and the EGF like domains involved in cell adhesion and receptor ligand interactions. This particular member is a developmentally regulated, neural specific gene which plays an unspecified role in early embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion G protein-coupled receptor C1; Cadherin EGF LAG seven-pass G-type receptor 1; Cadherin family member 9; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); Flamingo homolog 2; hFmi2; protocadherin flamingo 2
Gene Aliases: ADGRC1; CDHF9; CELSR1; FMI2; HFMI2; ME2
UniProt ID: (Human) O95722
Entrez Gene ID: (Human) 9620
establishment of planar polarity
neuron migration
neural tube closure
hair follicle development
homophilic cell adhesion via plasma membrane adhesion molecules
G-protein coupled receptor signaling pathway
Rho protein signal transduction
central nervous system development
locomotory behavior
anterior/posterior pattern specification
regulation of actin cytoskeleton organization
wound healing
establishment of planar polarity of embryonic epithelium
inner ear morphogenesis
apical protein localization
establishment of body hair planar orientation
Wnt signaling pathway, planar cell polarity pathway
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
lateral sprouting involved in lung morphogenesis
planar cell polarity pathway involved in neural tube closure
protein localization involved in establishment of planar polarity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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