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Invitrogen
CELSR3 Polyclonal Antibody
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Product Details
PA5-33425
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 19 amino acid peptide from N-terminal extracellular domain of human CELSR3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550805
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%) Monkey (89%) Marmoset (84%).
Target Information
CELSR3 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion G protein-coupled receptor C3; anchor protein; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); EGF-like protein 1; EGF-like-domain, multiple 1; Epidermal growth factor-like protein 1; Flamingo homolog 1; hFmi1; Megf3; Multiple EGF-like domains protein 2; Multiple epidermal growth factor-like domains protein 2
Gene Aliases: ADGRC3; CDHF11; CELSR3; EGFL1; FMI1; HFMI1; KIAA0812; MEGF2; RESDA1
UniProt ID: (Human) Q9NYQ7
Entrez Gene ID: (Human) 1951
neuron migration
regulation of protein phosphorylation
homophilic cell adhesion via plasma membrane adhesion molecules
G-protein coupled receptor signaling pathway
axonal fasciculation
regulation of protein localization
dopaminergic neuron axon guidance
serotonergic neuron axon guidance
cilium assembly
Wnt signaling pathway, planar cell polarity pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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