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Active Motif
CENP-E Monoclonal Antibody (1H12)
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Product Details
39619
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
1H12
Immunogen
This CENP-E antibody was raised against full-length human CENP-E protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
70mM tris, pH 8, with 31mM glycine, 30% glycerol, 105mM NaCl, 0.07mM EDTA
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2793278
Target Information
14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigmais the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to g-irradiation and other DNA-damaging agents. 14-3-3 sigmais a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-E; cenpe; centromere autoantigen E; Centromere autoantigen E (312kD); Centromere protein E; centromere protein E, 312kDa; Centromere-associated protein E; centromeric protein E; KIF10; kinesin 10; kinesin family member 10; Kinesin superfamily protein 10; Kinesin-7; Kinesin-related protein CENPE; Motor domain of KIF10; N-7 kinesin; protein phosphatase 1, regulatory subunit 61
Gene Aliases: 312kDa; AU019344; BC049989; C530022J18; CENP-E; CENPE; KIF10; MCPH13; PPP1R61
UniProt ID: (Human) Q02224, (Mouse) Q6RT24
Entrez Gene ID: (Human) 1062, (Mouse) 229841
mitotic cell cycle
microtubule-based movement
cell cycle
chromosome segregation
mitotic nuclear division
mitotic metaphase plate congression
regulation of mitotic nuclear division
mitotic spindle assembly checkpoint
multicellular organism development
metabolic process
attachment of spindle microtubules to kinetochore
regulation of mitotic metaphase/anaphase transition
establishment of protein localization
positive regulation of mitotic metaphase/anaphase transition
positive regulation of protein kinase activity
regulation of developmental process
cell division
attachment of mitotic spindle microtubules to kinetochore
positive regulation of chromosome segregation
positive regulation of attachment of spindle microtubules to kinetochore
retrograde vesicle-mediated transport, Golgi to ER
sister chromatid cohesion
mitotic chromosome movement towards spindle pole
antigen processing and presentation of exogenous peptide antigen via MHC class II
kinetochore assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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