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Invitrogen
CENPO Polyclonal Antibody
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Product Details
PA5-20826
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide from near the center of human CENPO.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153805
Product Specific Information
A suggested positive control is mouse kidney tissue lysate.
PA5-20826 can be used with blocking peptide PEP-0940.
Target Information
Accurate chromosome segregation during mitosis requires a kinetochore to assemble correctly at the centromere of each chromatid and form a dynamic interface with the microtubules of the mitotic spindle. The kinetochore assembly includes the multisubunit CENP-H/I complex which can be divided into three functional classes based on phenotype analysis. One of these classes is referred to as the CENP-O class of proteins of which CENPO is the exemplar. These proteins form a stable complex with each other and are required for proper kinetochore function and for recovery from mitotic spindle damage. CENPO has also been shown to be an auto-antigen in a small population of anti-centromere antibodies- (ACA-) positive patients with sclerodoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CENP-O; Centromere protein O; centromeric protein O; Interphase centromere complex protein 36
Gene Aliases: 2810429O05Rik; 8430427C03Rik; CENP-O; CENPO; D12Ertd482e; ICEN-36; ICEN36; MCM21R
UniProt ID: (Human) Q9BU64, (Mouse) Q8K015
Entrez Gene ID: (Human) 79172, (Mouse) 52504, (Rat) 684439
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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