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Proteintech
CEP135 Polyclonal Antibody
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Product Details
24428-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CEP135 Fusion Protein Ag19122 (1-233 aa encoded by BC136535)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTTAVERKY INIRKRLDQL GYRQTLTVEC LPLVEKLFSD LVHTTESLRQ SKLSAVKAEK ESANFDFVLE PYKLENARLS RENNELYLEL MKLREHSDQH VKELKTSLKK CARETADLKF LNNQYAHKLK LLEKESKAKN ERIQQLQEKN LHAVVQTPGG KKRSIAFRRQ RMQIDEPVPP SEVSSYPVPQ PDDPYIADLL QVADNRIQEL QQEVHQLQEK LAMMESGVRD YSKQ (1-233 aa encoded by BC136535)
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: centrosomal protein 135kDa; Centrosomal protein 4; Centrosomal protein of 135 kDa; centrosome protein cep135; Cep135
Gene Aliases: CEP135; CEP4; KIAA0635; MCPH8
UniProt ID: (Human) Q66GS9
Entrez Gene ID: (Dog) 482157, (Human) 9662
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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