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Invitrogen
CEP170 Polyclonal Antibody
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FIGURE: 1 / 2
CEP170 Antibody (PA5-101508) in ICC/IF
Immunocytochemistry analysis of CEP170 in HepG2 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CEP170 polyclonal antibody (Product # PA5-101508) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
Product Details
PA5-101508
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CEP170(Accession Q5SW79), corresponding to amino acid residues V705-E755.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2850943
Product Specific Information
Antibody detects endogenous levels of total CEP170.
Target Information
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: centrosomal protein 170kDa; Centrosomal protein of 170 kDa; Cep170; KARP-1-binding protein; KARP1-binding protein; XRCC5 binding protein
Gene Aliases: 4933426L22Rik; A330004A13Rik; AI195353; CEP170; FAM68A; KAB; KIAA0470
UniProt ID: (Human) Q5SW79, (Mouse) Q6A065
Entrez Gene ID: (Human) 9859, (Mouse) 545389
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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