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Invitrogen
CEP290 Polyclonal Antibody
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CEP290 Antibody (PA5-36580) in WB
Western blot analysis of CEP290 in Lane 1: HCT116 whole cell lysate (40 µg), Lane 2: SGC7901 whole cell lysate (40 µg), Lane 3: COS-7 whole cell lysate (40 µg), Lane 4: A549 whole cell lysate (40 µg), Lane 5: CT26 whole cell lysate (40 µg), Lane 6: AML-12 whole cell lysate (40 µg), Lane 7: PC12 whole cell lysate (40 µg). Samples were incubated with CEP290 polyclonal antibody (Product # PA5-36580) at a dilution of 1:500.
Product Details
PA5-36580
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 781-830 of human CEP290
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553597
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 290 kDa.
Purity is >95% by SDS-PAGE.
Target Information
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 14 protein; Bardet-Biedl syndrome 14 protein homolog; Cancer/testis antigen 87; centrosomal protein 290kDa; Centrosomal protein of 290 kDa; Cep290; CT87; CTCL tumor antigen se2-2; Meckel syndrome, type 4; monoclonal antibody 3H11 antigen; Nephrocystin-6; nephrocytsin-6; POC3 centriolar protein homolog; prostate cancer antigen T21; Tumor antigen se2-2
Gene Aliases: 3H11Ag; b2b1454Clo; b2b1752Clo; BBS14; BC004690; CEP290; CT87; JBTS5; KIAA0373; LCA10; MKS4; NPHP6; POC3; rd16; RGD1311640; SLSN6
UniProt ID: (Human) O15078, (Mouse) Q6A078
Entrez Gene ID: (Human) 80184, (Mouse) 216274, (Rat) 314787
G2/M transition of mitotic cell cycle
protein transport
hindbrain development
otic vesicle formation
cilium assembly
eye photoreceptor cell development
positive regulation of transcription, DNA-templated
pronephros development
cilium morphogenesis
regulation of establishment of protein localization
positive regulation of intracellular protein transport
transcription, DNA-templated
regulation of transcription, DNA-templated
transport
establishment or maintenance of cell polarity
cell projection organization
regulation of cAMP metabolic process
nonmotile primary cilium assembly
photoreceptor cell maintenance
retina development in camera-type eye
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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