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Invitrogen
CEP290 Polyclonal Antibody
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Product Details
PA5-84641
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CEP290. Recombinant protein control fragment (Product #RP-107333).
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2791792
Product Specific Information
Immunogen sequence: IIPSLERLVN AIESKNAEGI FDASLHLKAQ VDQLTGRNEE LRQELRESRK EAINYSQQLA KANLKIDHLE KETSLLRQSE GSNVVFKGID LPDGIAPSSA SII
Target Information
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 14 protein; Cancer/testis antigen 87; centrosomal protein 290kDa; Centrosomal protein of 290 kDa; Cep290; CT87; CTCL tumor antigen se2-2; Meckel syndrome, type 4; monoclonal antibody 3H11 antigen; Nephrocystin-6; nephrocytsin-6; POC3 centriolar protein homolog; prostate cancer antigen T21; Tumor antigen se2-2
Gene Aliases: 3H11Ag; BBS14; CEP290; CT87; JBTS5; KIAA0373; LCA10; MKS4; NPHP6; POC3; rd16; SLSN6
UniProt ID: (Human) O15078
Entrez Gene ID: (Human) 80184
G2/M transition of mitotic cell cycle
protein transport
hindbrain development
otic vesicle formation
cilium assembly
eye photoreceptor cell development
positive regulation of transcription, DNA-templated
pronephros development
cilium morphogenesis
regulation of establishment of protein localization
positive regulation of intracellular protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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