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Invitrogen
CFC1B/CFC1 Polyclonal Antibody
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Product Details
PA5-75660
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues in Human CFC1B/CFC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719388
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellular and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins. Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrulation. Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects. Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cryptic family protein 1; Cryptic family protein 1B; Cryptic protein; heterotaxy 2 (autosomal dominant)
Gene Aliases: AV265756; b2b970Clo; CFC1; CFC1B; CRYPTIC; DTGA2; HTX2; RGD1562188
UniProt ID: (Human) P0CG37, (Human) P0CG36, (Mouse) P97766
Entrez Gene ID: (Human) 55997, (Human) 653275, (Rat) 501121, (Mouse) 12627
liver development
heart looping
heart morphogenesis
determination of left/right symmetry
endoderm development
post-embryonic development
anterior/posterior pattern specification
BMP signaling pathway
nodal signaling pathway
spleen development
digestive tract morphogenesis
anatomical structure development
canonical Wnt signaling pathway
atrial septum morphogenesis
left lung morphogenesis
respiratory system development
gastrulation
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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