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CGRP Polyclonal Antibody

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View all (20) CGRP antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSC00190W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from mouse CGRP conjugated to blue carrier protein was used as the antigen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: CGRP.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Alpha-type CGRP; Calcitonin; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; MGC126648; RAT calcitonin

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Gene Aliases: CA; Cal1; CAL6; Calc; Calc1; Calca; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6

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UniProt ID: (Rat) P01257, (Mouse) P70160

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Entrez Gene ID: (Rat) 24241, (Mouse) 12310

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Function(s)
receptor binding neuropeptide hormone activity calcitonin receptor binding protein complex binding identical protein binding hormone activity
Process(es)
endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis inflammatory response leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway neuromuscular junction development embryo implantation aging feeding behavior regulation of heart contraction regulation of blood pressure response to heat negative regulation of calcium ion transport into cytosol negative regulation of ossification positive regulation of cAMP biosynthetic process receptor internalization negative regulation of neurological system process activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation positive regulation of adenylate cyclase activity negative regulation of blood pressure positive regulation of ossification negative regulation of bone resorption positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus sperm capacitation mitophagy in response to mitochondrial depolarization
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