Invitrogen

CGRP Polyclonal Antibody

View all (20) CGRP antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-114931

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CALCA(Accession P06881), corresponding to amino acid residues G96-G120.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899567

Product Specific Information

Antibody detects endogenous levels of total Calcitonin.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-type CGRP; Calcitonin; calcitonin 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; MGC126648; RAT calcitonin

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Gene Aliases: CA; Cal1; CAL6; Calc; CALC1; CALCA; calcitonin; CGRP; CGRP-1; CGRP-I; CGRP1; CT; Ctn; KC; PCT; RATCAL6

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UniProt ID: (Human) P01258, (Rat) P01257, (Mouse) P70160

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Entrez Gene ID: (Human) 796, (Rat) 24241, (Mouse) 12310

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Function(s)
hormone activity protein binding calcitonin receptor binding identical protein binding receptor binding neuropeptide hormone activity protein complex binding
Process(es)
endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation cellular calcium ion homeostasis inflammatory response leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration neuropeptide signaling pathway neuromuscular junction development embryo implantation aging feeding behavior regulation of heart contraction regulation of blood pressure response to heat negative regulation of calcium ion transport into cytosol negative regulation of ossification positive regulation of cAMP biosynthetic process receptor internalization negative regulation of neurological system process activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration positive regulation of macrophage differentiation negative regulation of osteoclast differentiation positive regulation of adenylate cyclase activity negative regulation of blood pressure positive regulation of ossification negative regulation of bone resorption positive regulation of cell adhesion negative regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of smooth muscle contraction response to pain detection of temperature stimulus involved in sensory perception of pain regulation of cytosolic calcium ion concentration positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus cellular protein metabolic process sperm capacitation mitophagy in response to mitochondrial depolarization
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