Proteintech

CHAC1 Polyclonal Antibody

CHAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CHAC1 Antibody (15207-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach tissue slide using 15207-1-AP (CHAC1 antibody) at dilution of 1:200 (under 40x lens).

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Product Details

15207-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHAC1 Fusion Protein Ag7360 (1-222 aa encoded by BC001847)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKQESAAPN TPPTSQSPTP SAQFPRNDGD PQALWIFGYG SLVWRPDFAY SDSRVGFVRG YSRRFWQGDT FHRGSDKMPG RVVTLLEDHE GCTWGVAYQV QGEQVSKALK YLNVREAVLG GYDTKEVTFY PQDAPDQPLK ALAYVATPQN PGYLGPAPEE AIATQILACR GFSGHNLEYL LRLADFMQLC GPQAQDEHLA AIVDAVGTML PCFCPTEQAL ALV (1-222 aa encoded by BC001847)

Target Information

Pro-apoptotic component of the unfolded protein response pathway. May mediate the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells.

Laboratory investigation; a journal of technical methods and pathology

Li X,Xiong W,Wang Y,Li Y,Cheng X,Liu W

Mon May 01 00:00:00 UTC 2023

Treatment with paraquat affects the expression of ferroptosis-related genes.

Human & experimental toxicology

Ge X,Cai Q,Zhang S,Wu X,Ying P,Ke J,Yang Z

Mon Mar 27 00:00:00 UTC 2023

CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage.

International journal of molecular sciences

Liu Y,Wu D,Fu Q,Hao S,Gu Y,Zhao W,Chen S,Sheng F,Xu Y,Chen Z,Yao K

Fri Jan 13 00:00:00 UTC 2023

Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.

Proceedings of the National Academy of Sciences of the United States of America

Crabtree AA,Boehnke N,Bates FS,Hackel BJ

Tue May 02 00:00:00 UTC 2023

Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells.

Cell death & disease

Seo MJ,Kim IY,Lee DM,Park YJ,Cho MY,Jin HJ,Choi KS

Thu Jan 19 00:00:00 UTC 2023

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis.

Journal of nanobiotechnology

Wang Y,Niu H,Li L,Han J,Liu Z,Chu M,Sha X,Zhao J

Mon Mar 27 00:00:00 UTC 2023

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis.

Journal of nanobiotechnology

Wang Y,Niu H,Li L,Han J,Liu Z,Chu M,Sha X,Zhao J

Mon Mar 27 00:00:00 UTC 2023

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.

Signal transduction and targeted therapy

Yuan Y,Mei Z,Qu Z,Li G,Yu S,Liu Y,Liu K,Shen Z,Pu J,Wang Y,Wang C,Sun Z,Liu Q,Pang X,Wang A,Ren Z,Wang T,Liu Y,Hong J,Xie J,Li X,Wang Z,Du W,Yang B

Mon Mar 27 00:00:00 UTC 2023

Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.

Journal of ethnopharmacology

Wang X,He MJ,Chen XJ,Bai YT,Zhou G

Mon May 23 00:00:00 UTC 2022

Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.

Journal of ethnopharmacology

Wang X,He MJ,Chen XJ,Bai YT,Zhou G

Mon May 23 00:00:00 UTC 2022

Glaucocalyxin A impairs tumor growth via amplification of the ATF4/CHOP/CHAC1 cascade in human oral squamous cell carcinoma.

Journal of ethnopharmacology

Wang X,He MJ,Chen XJ,Bai YT,Zhou G

Mon May 23 00:00:00 UTC 2022

Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.

Cellular and molecular gastroenterology and hepatology

Huang S,Wang Y,Xie S,Lai Y,Mo C,Zeng T,Kuang S,Deng G,Zhou C,Chen Y,Huang S,Gao L,Lv Z

Thu May 19 00:00:00 UTC 2022

Journal of cellular and molecular medicine

Xiao R,Wang S,Guo J,Liu S,Ding A,Wang G,Li W,Zhang Y,Bian X,Zhao S,Qiu W

Tue Feb 01 00:00:00 UTC 2022

DJ-1 inhibits glutathione degradation by downregulating CHAC1 expression in astrocytes.

Neuroscience research

Ge Y,Zheng X,Mao S,Zhang Q,Hu G,Wei Y

Tue Nov 01 00:00:00 UTC 2022

Differences in cell death in methionine versus cysteine depletion.

Environmental and molecular mutagenesis

Wallis KF,Morehead LC,Bird JT,Byrum SD,Miousse IR

Mon Mar 01 00:00:00 UTC 2021

Journal of cellular and molecular medicine

Li D,Liu S,Xu J,Chen L,Xu C,Chen F,Xu Z,Zhang Y,Xia S,Shao Y,Wang Y

Thu Apr 01 00:00:00 UTC 2021

Journal of cellular and molecular medicine

Li D,Liu S,Xu J,Chen L,Xu C,Chen F,Xu Z,Zhang Y,Xia S,Shao Y,Wang Y

Thu Apr 01 00:00:00 UTC 2021

High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway.

Free radical biology & medicine

Zhang X,Li W,Ma Y,Zhao X,He L,Sun P,Wang H

Wed Dec 01 00:00:00 UTC 2021

Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion.

Innate immunity

Yuyun X,Fan Y,Weiping W,Qing Y,Bingwei S

Fri Jan 01 00:00:00 UTC 2021

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level.

Chemico-biological interactions

Tomonobu N,Komalasari NLGY,Sumardika IW,Jiang F,Chen Y,Yamamoto KI,Kinoshita R,Murata H,Inoue Y,Sakaguchi M

Mon Jun 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Blocks Notch protein; Botch; cation transport regulator homolog 1; Cation transport regulator-like protein 1; ChaC glutathione-specific gamma-glutamylcyclotransferase 1; ChaC, cation transport regulator homolog 1; ChaC, cation transport regulator homolog 1 (E. coli); ChaC, cation transport regulator-like 1; Gamma-GCG 1; gamma-GCT acting on glutathione homolog 1; Glutathione-specific gamma-glutamylcyclotransferase 1; Neuroprotective protein 7

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Gene Aliases: 1810008K03Rik; BOTCH; CHAC1; Npg7; RGD1307153

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UniProt ID: (Human) Q9BUX1, (Mouse) Q8R3J5, (Rat) B3STU3

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Entrez Gene ID: (Human) 79094, (Mouse) 69065, (Chinese hamster) 100762174, (Rat) 362196

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Function(s)

gamma-glutamylcyclotransferase activity Notch binding protein binding transferase activity transferase activity, transferring acyl groups

Process(es)

glutathione biosynthetic process response to unfolded protein Notch signaling pathway negative regulation of protein processing neurogenesis negative regulation of Notch signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress apoptotic process nervous system development metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHAC1 Polyclonal Antibody

CHAC1 Antibody (15207-1-AP) in IHC (P)

Product Details

15207-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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