Proteintech

CHCHD10 Polyclonal Antibody

CHCHD10 Antibody in Immunocytochemistry (ICC/IF)

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CHCHD10 Antibody (25671-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HeLa cells using CHCHD10 antibody (Product # 25671-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red).

CHCHD10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CHCHD10 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

25671-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHCHD10 Fusion Protein Ag22598 (82-142 aa encoded by BC065232)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QPAVQQAPT PAAPQPLQMG PCAYEIRQFL DCSTTQSDLS LCEGFSEALK QCKYYHGLSS LP (82-142 aa encoded by BC065232)

Target Information

CHCHD10 encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.

Cell reports

Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G

Tue Mar 08 00:00:00 UTC 2022

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Cell death & disease

Ruan Y,Hu J,Che Y,Liu Y,Luo Z,Cheng J,Han Q,He H,Zhou Q

Wed Feb 16 00:00:00 UTC 2022

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Cells

Li H,Peng H,Hong W,Wei Y,Tian H,Huang X,Jia L,Zheng J,Duan T,He Q,Wang K

Sun Dec 25 00:00:00 UTC 2022

Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.

Molecular therapy. Nucleic acids

Stein CS,McLendon JM,Witmer NH,Boudreau RL

Tue Jun 14 00:00:00 UTC 2022

Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.

Human molecular genetics

Nguyen MK,McAvoy K,Liao SC,Doric Z,Lo I,Li H,Manfredi G,Nakamura K

Wed May 04 00:00:00 UTC 2022

Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.

Human molecular genetics

Nguyen MK,McAvoy K,Liao SC,Doric Z,Lo I,Li H,Manfredi G,Nakamura K

Wed May 04 00:00:00 UTC 2022

CHCHD10 Modulates Thermogenesis of Adipocytes by Regulating Lipolysis.

Diabetes

Ding M,Ma YJ,Du RQ,Zhou WY,Dou X,Yang QQ,Tang Y,Qian SW,Liu Y,Pan DN,Tang QQ,Liu Y

Thu Sep 01 00:00:00 UTC 2022

TDP-43 and PINK1 mediate CHCHD10^S59L mutation-induced defects in Drosophila and in vitro.

Nature communications

Baek M,Choe YJ,Bannwarth S,Kim J,Maitra S,Dorn GW,Taylor JP,Paquis-Flucklinger V,Kim NC

Fri Mar 26 00:00:00 UTC 2021

Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.

Human molecular genetics

Xiao Y,Zhang J,Shu X,Bai L,Xu W,Wang A,Chen A,Tu WY,Wang J,Zhang K,Luo B,Shen C

Tue Jul 21 00:00:00 UTC 2020

Loss of mitochondrial protein CHCHD10 in skeletal muscle causes neuromuscular junction impairment.

Human molecular genetics

Xiao Y,Zhang J,Shu X,Bai L,Xu W,Wang A,Chen A,Tu WY,Wang J,Zhang K,Luo B,Shen C

Tue Jul 21 00:00:00 UTC 2020

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Human molecular genetics

Zhou W,Ma D,Sun AX,Tran HD,Ma DL,Singh BK,Zhou J,Zhang J,Wang D,Zhao Y,Yen PM,Goh E,Tan EK

Mon Apr 01 00:00:00 UTC 2019

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Human molecular genetics

Zhou W,Ma D,Sun AX,Tran HD,Ma DL,Singh BK,Zhou J,Zhang J,Wang D,Zhao Y,Yen PM,Goh E,Tan EK

Mon Apr 01 00:00:00 UTC 2019

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Human molecular genetics

Zhou W,Ma D,Sun AX,Tran HD,Ma DL,Singh BK,Zhou J,Zhang J,Wang D,Zhao Y,Yen PM,Goh E,Tan EK

Mon Apr 01 00:00:00 UTC 2019

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction.

Human molecular genetics

Zhou W,Ma D,Sun AX,Tran HD,Ma DL,Singh BK,Zhou J,Zhang J,Wang D,Zhao Y,Yen PM,Goh E,Tan EK

Mon Apr 01 00:00:00 UTC 2019

Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum.

Journal of molecular cell biology

Peng J,Sheng AL,Xiao Q,Shen L,Ju XC,Zhang M,He ST,Wu C,Luo ZG

Mon Aug 19 00:00:00 UTC 2019

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency.

Human molecular genetics

Brockmann SJ,Freischmidt A,Oeckl P,Müller K,Ponna SK,Helferich AM,Paone C,Reinders J,Kojer K,Orth M,Jokela M,Auranen M,Udd B,Hermann A,Danzer KM,Lichtner P,Walther P,Ludolph AC,Andersen PM,Otto M,Kursula P,Just S,Weishaupt JH

Thu Feb 15 00:00:00 UTC 2018

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Nature communications

Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE

Tue Jun 06 00:00:00 UTC 2017

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Nature communications

Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE

Tue Jun 06 00:00:00 UTC 2017

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Nature communications

Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE

Tue Jun 06 00:00:00 UTC 2017

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity.

Nature communications

Woo JA,Liu T,Trotter C,Fang CC,De Narvaez E,LePochat P,Maslar D,Bukhari A,Zhao X,Deonarine A,Westerheide SD,Kang DE

Tue Jun 06 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; Nur77 downstream gene 2; Nur77 downstream protein 2; Protein N27C7-4

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Gene Aliases: 1620401E04Rik; AI267078; C22orf16; CHCHD10; FTDALS2; IMMD; N27C7-4; Ndg2; SMAJ

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UniProt ID: (Human) Q8WYQ3

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Entrez Gene ID: (Human) 400916, (Mouse) 103172

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Function(s)

molecular_function

Process(es)

oxidative phosphorylation ATP biosynthetic process mitochondrion organization negative regulation of ATP citrate synthase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHCHD10 Polyclonal Antibody

CHCHD10 Antibody (25671-1-AP) in ICC/IF

Product Details

25671-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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