Product References
Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy.
Cell reports
Sayles NM,Southwell N,McAvoy K,Kim K,Pesini A,Anderson CJ,Quinzii C,Cloonan S,Kawamata H,Manfredi G
Tue Mar 08 00:00:00 UTC 2022
CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.
Cell death & disease
Ruan Y,Hu J,Che Y,Liu Y,Luo Z,Cheng J,Han Q,He H,Zhou Q
Wed Feb 16 00:00:00 UTC 2022
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Human molecular genetics
Nguyen MK,McAvoy K,Liao SC,Doric Z,Lo I,Li H,Manfredi G,Nakamura K
Wed May 04 00:00:00 UTC 2022
Mouse midbrain dopaminergic neurons survive loss of the PD-associated mitochondrial protein CHCHD2.
Human molecular genetics
Nguyen MK,McAvoy K,Liao SC,Doric Z,Lo I,Li H,Manfredi G,Nakamura K
Wed May 04 00:00:00 UTC 2022
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
iScience
Purandare N,Kunji Y,Xi Y,Romero R,Gomez-Lopez N,Fribley A,Grossman LI,Aras S
Fri Nov 18 00:00:00 UTC 2022
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
iScience
Purandare N,Kunji Y,Xi Y,Romero R,Gomez-Lopez N,Fribley A,Grossman LI,Aras S
Fri Nov 18 00:00:00 UTC 2022
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
iScience
Purandare N,Kunji Y,Xi Y,Romero R,Gomez-Lopez N,Fribley A,Grossman LI,Aras S
Fri Nov 18 00:00:00 UTC 2022
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
iScience
Purandare N,Kunji Y,Xi Y,Romero R,Gomez-Lopez N,Fribley A,Grossman LI,Aras S
Fri Nov 18 00:00:00 UTC 2022
SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway.
Journal of virology
Chen DY,Khan N,Close BJ,Goel RK,Blum B,Tavares AH,Kenney D,Conway HL,Ewoldt JK,Chitalia VC,Crossland NA,Chen CS,Kotton DN,Baker SC,Fuchs SY,Connor JH,Douam F,Emili A,Saeed M
Thu Sep 09 00:00:00 UTC 2021
TDP-43 and PINK1 mediate CHCHD10S59L mutation-induced defects in Drosophila and in vitro.
Nature communications
Baek M,Choe YJ,Bannwarth S,Kim J,Maitra S,Dorn GW,Taylor JP,Paquis-Flucklinger V,Kim NC
Fri Mar 26 00:00:00 UTC 2021
Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies.
Frontiers in cell and developmental biology
Smith AST,Chun C,Hesson J,Mathieu J,Valdmanis PN,Mack DL,Choi BO,Kim DH,Bothwell M
Fri Mar 04 00:00:00 UTC 2022
Molecular mechanisms regulating lysophosphatidylcholine acyltransferase 1 (LPCAT1) in human pregnancy.
Placenta
Purandare N,Minchella P,Somayajulu M,Kramer KJ,Zhou J,Adekoya N,Welch RA,Grossman LI,Aras S,Recanati MA
Mon Mar 01 00:00:00 UTC 2021
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA.
Cells
Key J,Torres-Odio S,Bach NC,Gispert S,Koepf G,Reichlmeir M,West AP,Prokisch H,Freisinger P,Newman WG,Shalev S,Sieber SA,Wittig I,Auburger G
Mon Nov 29 00:00:00 UTC 2021
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Aras S,Purandare N,Gladyck S,Somayajulu-Nitu M,Zhang K,Wallace DC,Grossman LI
Tue Dec 15 00:00:00 UTC 2020
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Human molecular genetics
Liu YT,Huang X,Nguyen D,Shammas MK,Wu BP,Dombi E,Springer DA,Poulton J,Sekine S,Narendra DP
Wed Jun 03 00:00:00 UTC 2020
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Human molecular genetics
Liu YT,Huang X,Nguyen D,Shammas MK,Wu BP,Dombi E,Springer DA,Poulton J,Sekine S,Narendra DP
Wed Jun 03 00:00:00 UTC 2020
Decreased membrane cholesterol in liver mitochondria of the point mutation mouse model of juvenile Niemann-Pick C1, Npc1nmf164.
Mitochondrion
Erickson RP,Aras S,Purandare N,Hüttemann M,Liu J,Dragotto J,Fiorenza MT,Grossman LI
Sun Mar 01 00:00:00 UTC 2020
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
bioRxiv : the preprint server for biology
Chen DY,Khan N,Close BJ,Goel RK,Blum B,Tavares AH,Kenney D,Conway HL,Ewoldt JK,Kapell S,Chitalia VC,Crossland NA,Chen CS,Kotton DN,Baker SC,Connor JH,Douam F,Emili A,Saeed M
Wed Oct 28 00:00:00 UTC 2020
Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis.
BMC cancer
Aras S,Maroun MC,Song Y,Bandyopadhyay S,Stark A,Yang ZQ,Long MP,Grossman LI,Fernández-Madrid F
Thu May 02 00:00:00 UTC 2019
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
The Journal of cell biology
Papadopoulos N,Lennartsson J,Heldin CH
Mon May 07 00:00:00 UTC 2018
PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
The Journal of cell biology
Papadopoulos N,Lennartsson J,Heldin CH
Mon May 07 00:00:00 UTC 2018
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics
Burstein SR,Valsecchi F,Kawamata H,Bourens M,Zeng R,Zuberi A,Milner TA,Cloonan SM,Lutz C,Barrientos A,Manfredi G
Mon Jan 01 00:00:00 UTC 2018
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics
Burstein SR,Valsecchi F,Kawamata H,Bourens M,Zeng R,Zuberi A,Milner TA,Cloonan SM,Lutz C,Barrientos A,Manfredi G
Mon Jan 01 00:00:00 UTC 2018
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics
Burstein SR,Valsecchi F,Kawamata H,Bourens M,Zeng R,Zuberi A,Milner TA,Cloonan SM,Lutz C,Barrientos A,Manfredi G
Mon Jan 01 00:00:00 UTC 2018
In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions.
Human molecular genetics
Burstein SR,Valsecchi F,Kawamata H,Bourens M,Zeng R,Zuberi A,Milner TA,Cloonan SM,Lutz C,Barrientos A,Manfredi G
Mon Jan 01 00:00:00 UTC 2018
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
The Journal of biological chemistry
Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S
Fri Apr 27 00:00:00 UTC 2018
The cellular stress proteins CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction.
The Journal of biological chemistry
Purandare N,Somayajulu M,Hüttemann M,Grossman LI,Aras S
Fri Apr 27 00:00:00 UTC 2018
Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection.
Journal of virology
Xin QL,Deng CL,Chen X,Wang J,Wang SB,Wang W,Deng F,Zhang B,Xiao G,Zhang LK
Thu Jun 15 00:00:00 UTC 2017
Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection.
Journal of virology
Xin QL,Deng CL,Chen X,Wang J,Wang SB,Wang W,Deng F,Zhang B,Xiao G,Zhang LK
Thu Jun 15 00:00:00 UTC 2017
Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.
Biochimica et biophysica acta. Molecular cell research
Aras S,Arrabi H,Purandare N,Hüttemann M,Kamholz J,Züchner S,Grossman LI
Wed Feb 01 00:00:00 UTC 2017
Abl2 kinase phosphorylates Bi-organellar regulator MNRR1 in mitochondria, stimulating respiration.
Biochimica et biophysica acta. Molecular cell research
Aras S,Arrabi H,Purandare N,Hüttemann M,Kamholz J,Züchner S,Grossman LI
Wed Feb 01 00:00:00 UTC 2017
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
Nature communications
Meng H,Yamashita C,Shiba-Fukushima K,Inoshita T,Funayama M,Sato S,Hatta T,Natsume T,Umitsu M,Takagi J,Imai Y,Hattori N
Wed Jun 07 00:00:00 UTC 2017
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
Nature communications
Meng H,Yamashita C,Shiba-Fukushima K,Inoshita T,Funayama M,Sato S,Hatta T,Natsume T,Umitsu M,Takagi J,Imai Y,Hattori N
Wed Jun 07 00:00:00 UTC 2017
Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Xu X,Tay Y,Sim B,Yoon SI,Huang Y,Ooi J,Utami KH,Ziaei A,Ng B,Radulescu C,Low D,Ng AYJ,Loh M,Venkatesh B,Ginhoux F,Augustine GJ,Pouladi MA
Tue Mar 14 00:00:00 UTC 2017
Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Xu X,Tay Y,Sim B,Yoon SI,Huang Y,Ooi J,Utami KH,Ziaei A,Ng B,Radulescu C,Low D,Ng AYJ,Loh M,Venkatesh B,Ginhoux F,Augustine GJ,Pouladi MA
Tue Mar 14 00:00:00 UTC 2017
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
The Lancet. Neurology
Funayama M,Ohe K,Amo T,Furuya N,Yamaguchi J,Saiki S,Li Y,Ogaki K,Ando M,Yoshino H,Tomiyama H,Nishioka K,Hasegawa K,Saiki H,Satake W,Mogushi K,Sasaki R,Kokubo Y,Kuzuhara S,Toda T,Mizuno Y,Uchiyama Y,Ohno K,Hattori N
Sun Mar 01 00:00:00 UTC 2015
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
The Lancet. Neurology
Funayama M,Ohe K,Amo T,Furuya N,Yamaguchi J,Saiki S,Li Y,Ogaki K,Ando M,Yoshino H,Tomiyama H,Nishioka K,Hasegawa K,Saiki H,Satake W,Mogushi K,Sasaki R,Kokubo Y,Kuzuhara S,Toda T,Mizuno Y,Uchiyama Y,Ohno K,Hattori N
Sun Mar 01 00:00:00 UTC 2015
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
The Lancet. Neurology
Funayama M,Ohe K,Amo T,Furuya N,Yamaguchi J,Saiki S,Li Y,Ogaki K,Ando M,Yoshino H,Tomiyama H,Nishioka K,Hasegawa K,Saiki H,Satake W,Mogushi K,Sasaki R,Kokubo Y,Kuzuhara S,Toda T,Mizuno Y,Uchiyama Y,Ohno K,Hattori N
Sun Mar 01 00:00:00 UTC 2015
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
The Lancet. Neurology
Funayama M,Ohe K,Amo T,Furuya N,Yamaguchi J,Saiki S,Li Y,Ogaki K,Ando M,Yoshino H,Tomiyama H,Nishioka K,Hasegawa K,Saiki H,Satake W,Mogushi K,Sasaki R,Kokubo Y,Kuzuhara S,Toda T,Mizuno Y,Uchiyama Y,Ohno K,Hattori N
Sun Mar 01 00:00:00 UTC 2015
Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.
Proteomics
Li HY,Zhang LK,Zhu XJ,Shang J,Chen X,Zhu Y,Guo L
Sun Nov 01 00:00:00 UTC 2015
Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.
Proteomics
Li HY,Zhang LK,Zhu XJ,Shang J,Chen X,Zhu Y,Guo L
Sun Nov 01 00:00:00 UTC 2015
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Mitochondrion
Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI
Thu Jan 01 00:00:00 UTC 2015
MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.
Mitochondrion
Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI
Thu Jan 01 00:00:00 UTC 2015
Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.
Neurology
Ogaki K,Koga S,Heckman MG,Fiesel FC,Ando M,Labbé C,Lorenzo-Betancor O,Moussaud-Lamodière EL,Soto-Ortolaza AI,Walton RL,Strongosky AJ,Uitti RJ,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska M,Czyzewski K,Puschmann A,Nishioka K,Funayama M,Hattori N,Parisi JE,Petersen RC,Graff-Radford NR,Boeve BF,Springer W,Wszolek ZK,Dickson DW,Ross OA
Tue Dec 08 00:00:00 UTC 2015
Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.
Neurology
Ogaki K,Koga S,Heckman MG,Fiesel FC,Ando M,Labbé C,Lorenzo-Betancor O,Moussaud-Lamodière EL,Soto-Ortolaza AI,Walton RL,Strongosky AJ,Uitti RJ,McCarthy A,Lynch T,Siuda J,Opala G,Rudzinska M,Krygowska-Wajs A,Barcikowska M,Czyzewski K,Puschmann A,Nishioka K,Funayama M,Hattori N,Parisi JE,Petersen RC,Graff-Radford NR,Boeve BF,Springer W,Wszolek ZK,Dickson DW,Ross OA
Tue Dec 08 00:00:00 UTC 2015
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Nucleic acids research
Aras S,Pak O,Sommer N,Finley R,Hüttemann M,Weissmann N,Grossman LI
Fri Feb 01 00:00:00 UTC 2013
Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Nucleic acids research
Aras S,Pak O,Sommer N,Finley R,Hüttemann M,Weissmann N,Grossman LI
Fri Feb 01 00:00:00 UTC 2013
Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.
Human molecular genetics
Feyeux M,Bourgois-Rocha F,Redfern A,Giles P,Lefort N,Aubert S,Bonnefond C,Bugi A,Ruiz M,Deglon N,Jones L,Peschanski M,Allen ND,Perrier AL
Sat Sep 01 00:00:00 UTC 2012
Early transcriptional changes linked to naturally occurring Huntington's disease mutations in neural derivatives of human embryonic stem cells.
Human molecular genetics
Feyeux M,Bourgois-Rocha F,Redfern A,Giles P,Lefort N,Aubert S,Bonnefond C,Bugi A,Ruiz M,Deglon N,Jones L,Peschanski M,Allen ND,Perrier AL
Sat Sep 01 00:00:00 UTC 2012
