Proteintech

CHCHD2 Monoclonal Antibody (2G1G10)

CHCHD2 Antibody in Immunocytochemistry (ICC/IF)

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CHCHD2 Antibody (66302-1-IG) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 66302-1-IG (CHCHD2 antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

CHCHD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

66302-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Pig, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2G1G10

Immunogen

CHCHD2 Fusion Protein Ag24219 (1-151 aa encoded by BC003079)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPRGSRSRT SRMAPPASRA PQMRAAPRPA PVAQPPAAAP PSAVGSSAAA PRQPGLMAQM ATTAAGVAVG SAVGHTLGHA ITGGFSGGSN AEPARPDITY QEPQGTQPAQ QQQPCLYEIK QFLECAQNQG DIKLCEGFNE VLKQCRLANG LA (1-151 aa encoded by BC003079)

Target Information

Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress.

Proceedings of the National Academy of Sciences of the United States of America

Feng S,Desotell A,Ross A,Jovanovic M,Manley JL

Tue Feb 28 00:00:00 UTC 2023

A nucleolar long "non-coding" RNA encodes a novel protein that functions in response to stress.

Proceedings of the National Academy of Sciences of the United States of America

Feng S,Desotell A,Ross A,Jovanovic M,Manley JL

Tue Feb 28 00:00:00 UTC 2023

Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.

Acta neuropathologica communications

Liu X,Wang Q,Yang Y,Stewart T,Shi M,Soltys D,Liu G,Thorland E,Cilento EM,Hou Y,Liu Z,Feng T,Zhang J

Mon Mar 08 00:00:00 UTC 2021

Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.

Acta neuropathologica communications

Liu X,Wang Q,Yang Y,Stewart T,Shi M,Soltys D,Liu G,Thorland E,Cilento EM,Hou Y,Liu Z,Feng T,Zhang J

Mon Mar 08 00:00:00 UTC 2021

Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson's disease.

Acta neuropathologica communications

Liu X,Wang Q,Yang Y,Stewart T,Shi M,Soltys D,Liu G,Thorland E,Cilento EM,Hou Y,Liu Z,Feng T,Zhang J

Mon Mar 08 00:00:00 UTC 2021

Discovery of bactericides as an acute mitochondrial membrane damage inducer.

Molecular biology of the cell

Houston R,Sekine Y,Larsen MB,Murakami K,Mullett SJ,Wendell SG,Narendra DP,Chen BB,Sekine S

Mon Nov 01 00:00:00 UTC 2021

Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.

Proceedings of the National Academy of Sciences of the United States of America

Aras S,Purandare N,Gladyck S,Somayajulu-Nitu M,Zhang K,Wallace DC,Grossman LI

Tue Dec 15 00:00:00 UTC 2020

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.

Human molecular genetics

Liu YT,Huang X,Nguyen D,Shammas MK,Wu BP,Dombi E,Springer DA,Poulton J,Sekine S,Narendra DP

Wed Jun 03 00:00:00 UTC 2020

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.

Human molecular genetics

Straub IR,Janer A,Weraarpachai W,Zinman L,Robertson J,Rogaeva E,Shoubridge EA

Mon Jan 01 00:00:00 UTC 2018

CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.

Human molecular genetics