Proteintech

CHCHD4 Polyclonal Antibody

CHCHD4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 15

CHCHD4 Antibody (21090-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse testis tissue slide using 21090-1-AP ( CHCHD4 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CHCHD4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

21090-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHCHD4 Fusion Protein Ag15339 (1-142 aa encoded by BC033775)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSYCRQEGK DRIIFVTKED HETPSSAELV ADDPNDPYEE HGLILPNGNI NWNCPCLGGM ASGPCGEQFK SAFSCFHYST EEIKGSDCVD QFRAMQECMQ KYPDLYPQED EDEEEEREKK PAEQAEETAP IEATATKEEE GSS (1-142 aa encoded by BC033775)

Target Information

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Experimental & molecular medicine

Mao J,Wang D,Wang D,Wu Q,Shang Q,Gao C,Wang H,Wang H,Du M,Peng P,Jia H,Xu X,Wang J,Yang L,Luo Z

Sun Jan 01 00:00:00 UTC 2023

Experimental & molecular medicine

Mao J,Wang D,Wang D,Wu Q,Shang Q,Gao C,Wang H,Wang H,Du M,Peng P,Jia H,Xu X,Wang J,Yang L,Luo Z

Sun Jan 01 00:00:00 UTC 2023

Small heat shock proteins operate as molecular chaperones in the mitochondrial intermembrane space.

Nature cell biology

Adriaenssens E,Asselbergh B,Rivera-Mejías P,Bervoets S,Vendredy L,De Winter V,Spaas K,de Rycke R,van Isterdael G,Impens F,Langer T,Timmerman V

Wed Mar 01 00:00:00 UTC 2023

NOX4-TIM23 interaction regulates NOX4 mitochondrial import and metabolic reprogramming.

The Journal of biological chemistry

Pandey J,Larson-Casey JL,Patil MH,Joshi R,Jiang CS,Zhou Y,He C,Carter AB

Mon May 01 00:00:00 UTC 2023

Serine palmitoyltransferase assembles at ER-mitochondria contact sites.

Life science alliance

Aaltonen MJ,Alecu I,König T,Bennett SA,Shoubridge EA

Tue Feb 01 00:00:00 UTC 2022

Flow-induced endothelial mitochondrial remodeling mitigates mitochondrial reactive oxygen species production and promotes mitochondrial DNA integrity in a p53-dependent manner.

Redox biology

Shin J,Hong SG,Choi SY,Rath ME,Saredy J,Jovin DG,Sayoc J,Park HS,Eguchi S,Rizzo V,Scalia R,Wang H,Houser SR,Park JY

Fri Apr 01 00:00:00 UTC 2022

USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.

Discover oncology

Zhou Y,Zhao Y,Ma W,Zhang L,Jiang Y,Dong W

Thu Dec 08 00:00:00 UTC 2022

USF1-CHCHD4 axis promotes lung adenocarcinoma progression partially via activating the MYC pathway.

Discover oncology

Zhou Y,Zhao Y,Ma W,Zhang L,Jiang Y,Dong W

Thu Dec 08 00:00:00 UTC 2022

Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation.

Frontiers in oncology

Nedara K,Reinhardt C,Lebraud E,Arena G,Gracia C,Buard V,Pioche-Durieu C,Castelli F,Colsch B,Bénit P,Rustin P,Albaud B,Gestraud P,Baulande S,Servant N,Deutsch E,Verbavatz JM,Brenner C,Milliat F,Modjtahedi N

Fri Nov 18 00:00:00 UTC 2022

Bisphenol-A inhibits mitochondrial biogenesis via impairment of GFER mediated mitochondrial protein import in the rat brain hippocampus.

Neurotoxicology

Goyal S,Tiwari S,Seth B,Tandon A,Shankar J,Sinha M,Singh SJ,Priya S,Chaturvedi RK

Thu Jul 01 00:00:00 UTC 2021

Augmenter of liver regeneration regulates cellular iron homeostasis by modulating mitochondrial transport of ATP-binding cassette B8.

eLife

Chang HC,Shapiro JS,Jiang X,Senyei G,Sato T,Geier J,Sawicki KT,Ardehali H

Fri Apr 09 00:00:00 UTC 2021

Moschamindole induces glioma cell apoptosis by blocking Mia40-dependent mitochondrial intermembrane space assembly and oxidative respiration.

Phytotherapy research : PTR

Huang GD,Chen FF,Yang JH,Ma GX,Liao ZJ,Li WP,Li ZY,Chen L

Tue Jun 01 00:00:00 UTC 2021

Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.

Cell stem cell

Singh RP,Jeyaraju DV,Voisin V,Hurren R,Xu C,Hawley JR,Barghout SH,Khan DH,Gronda M,Wang X,Jitkova Y,Sharon D,Liyanagae S,MacLean N,Seneviratene AK,Mirali S,Borenstein A,Thomas GE,Soriano J,Orouji E,Minden MD,Arruda A,Chan SM,Bader GD,Lupien M,Schimmer AD

Thu Jun 04 00:00:00 UTC 2020

Dependence of PINK1 accumulation on mitochondrial redox system.

Aging cell

Gao F,Zhang Y,Hou X,Tao Z,Ren H,Wang G

Tue Sep 01 00:00:00 UTC 2020

Dependence of PINK1 accumulation on mitochondrial redox system.

Aging cell

Gao F,Zhang Y,Hou X,Tao Z,Ren H,Wang G

Tue Sep 01 00:00:00 UTC 2020

CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway.

Journal of experimental & clinical cancer research : CR

Babbar M,Huang Y,Curtiss CM,Sheikh MS

Thu Jun 20 00:00:00 UTC 2019

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

EMBO molecular medicine

Lehmer C,Schludi MH,Ransom L,Greiling J,Junghänel M,Exner N,Riemenschneider H,van der Zee J,Van Broeckhoven C,Weydt P,Heneka MT,Edbauer D

Fri Jun 01 00:00:00 UTC 2018

A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.

EMBO molecular medicine

Lehmer C,Schludi MH,Ransom L,Greiling J,Junghänel M,Exner N,Riemenschneider H,van der Zee J,Van Broeckhoven C,Weydt P,Heneka MT,Edbauer D

Fri Jun 01 00:00:00 UTC 2018

CHTM1, a novel metabolic marker deregulated in human malignancies.

Oncogene

Babbar M,Huang Y,An J,Landas SK,Sheikh MS

Sun Apr 01 00:00:00 UTC 2018

CHTM1, a novel metabolic marker deregulated in human malignancies.

Oncogene

Babbar M,Huang Y,An J,Landas SK,Sheikh MS

Sun Apr 01 00:00:00 UTC 2018

Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.

Biochimica et biophysica acta. Molecular basis of disease

Télot L,Rousseau E,Lesuisse E,Garcia C,Morlet B,Léger T,Camadro JM,Serre V

Sun Apr 01 00:00:00 UTC 2018

Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.

Biochimica et biophysica acta. Molecular basis of disease

Télot L,Rousseau E,Lesuisse E,Garcia C,Morlet B,Léger T,Camadro JM,Serre V

Sun Apr 01 00:00:00 UTC 2018

A disease-associated Aifm1 variant induces severe myopathy in knockin mice.

Molecular metabolism

Wischhof L,Gioran A,Sonntag-Bensch D,Piazzesi A,Stork M,Nicotera P,Bano D

Sun Jul 01 00:00:00 UTC 2018

A disease-associated Aifm1 variant induces severe myopathy in knockin mice.

Molecular metabolism

Wischhof L,Gioran A,Sonntag-Bensch D,Piazzesi A,Stork M,Nicotera P,Bano D

Sun Jul 01 00:00:00 UTC 2018

The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.

Pathology oncology research : POR

Balogh T,Lőrincz T,Stiller I,Mandl J,Bánhegyi G,Szarka A

Fri Apr 01 00:00:00 UTC 2016

The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.

Pathology oncology research : POR

Balogh T,Lőrincz T,Stiller I,Mandl J,Bánhegyi G,Szarka A

Fri Apr 01 00:00:00 UTC 2016

Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.

Molecular medicine (Cambridge, Mass.)

Song G,Napoli E,Wong S,Hagerman R,Liu S,Tassone F,Giulivi C

Sat Oct 01 00:00:00 UTC 2016

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Mitochondrion

Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI

Thu Jan 01 00:00:00 UTC 2015

MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism.

Mitochondrion

Aras S,Bai M,Lee I,Springett R,Hüttemann M,Grossman LI

Thu Jan 01 00:00:00 UTC 2015

Loss of apoptosis-inducing factor critically affects MIA40 function.

Cell death & disease

Meyer K,Buettner S,Ghezzi D,Zeviani M,Bano D,Nicotera P

Thu Jul 09 00:00:00 UTC 2015

Loss of apoptosis-inducing factor critically affects MIA40 function.

Cell death & disease

Meyer K,Buettner S,Ghezzi D,Zeviani M,Bano D,Nicotera P

Thu Jul 09 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; mitochondrial intermembrane space import and assembly 40 homolog; Mitochondrial intermembrane space import and assembly protein 40; translocase of inner mitochondrial membrane 40 homolog

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Gene Aliases: 2410012P20Rik; 2810014D17Rik; AI838740; CHCHD4; MIA40; TIMM40

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UniProt ID: (Human) Q8N4Q1, (Mouse) Q8VEA4, (Rat) Q5BJN5

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Entrez Gene ID: (Human) 131474, (Mouse) 72170, (Rat) 312559

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Function(s)

protein binding protein disulfide oxidoreductase activity oxidoreductase activity

Process(es)

transport protein transport protein maturation by protein folding cellular response to oxidative stress mitochondrial DNA repair protein import into mitochondrial intermembrane space regulation of protein export from nucleus 'de novo' posttranslational protein folding oxidation-reduction process establishment of protein localization to mitochondrion positive regulation of cellular respiration

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHCHD4 Polyclonal Antibody

CHCHD4 Antibody (21090-1-AP) in IHC (P)

Product Details

21090-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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