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CHI3L1 Polyclonal Antibody

CHI3L1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CHI3L1 Antibody (12036-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 12036-1-AP ( CHI3L1 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

12036-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CHI3L1 Fusion Protein Ag2710 (34-383 aa encoded by BC008568)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YREGDGSCF PDALDRFLCT HIIYSFANIS NDHIDTWEWN DVTLYGMLNT LKNRNPNLKT LLSVGGWNFG SQRFSKIASN TQSRRTFIKS VPPFLRTHGF DGLDLAWLYP GRRDKQHFTT LIKEMKAEFI KEAQPGKKQL LLSAALSAGK VTIDSSYDIA KISQHLDFIS IMTYDFHGAW RGTTGHHSPL FRGQEDASPD RFSNTDYAVG YMLRLGAPAS KLVMGIPTFG RSFTLASSET GVGAPISGPG IPGRFTKEAG TLAYYEICDF LRGATVHRIL GQQVPYATKG NQWVGYDDQE SVKSKVQYLK DRQLAGAMVW ALDLDDFQGS FCGQDLRFPL TNAIKDALAA T (34-383 aa encoded by BC008568)

Target Information

Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.

Journal of Cancer

Li L,Yang M,Pu X,Tang Y,Fei F,Li Z,Hou H,Chen Q,Wang Q,Wu Y,Zhang Y,Ren C,Gong A

Fri Sep 27 00:00:00 UTC 2024

Molecules of senescent glial cells differentiate Alzheimer's disease from ageing.

Journal of neurology, neurosurgery, and psychiatry

Dai L,Gao F,Wang Q,Lv X,Cheng Z,Wu Y,Chai X,Zetterberg H,Blennow K,Levey AI,Shi J,Shen Y

Sat Jul 01 00:00:00 UTC 2023

Hyaluronic acids mediate the infiltration, migration, and M2 polarization of macrophages: evaluating metabolic molecular phenotypes in gliomas.

Molecular oncology

Zhang H,Zhang N,Dai Z,Wang Z,Zhang X,Liang X,Zhang L,Feng S,Wu W,Ye W,Zhang J,Luo P,Liu Z,Cheng Q,Liu Z

Thu Dec 01 00:00:00 UTC 2022

Chitooligosaccharides Improve the Efficacy of Checkpoint Inhibitors in a Mouse Model of Lung Cancer.

Pharmaceutics

Johansen AZ,Carretta M,Thorseth ML,Khan S,Fjæstad KY,Brøchner CB,Linder H,Ankjærgaard C,Donia M,Chen I,Nielsen DL,Behrens CP,Madsen DH

Thu May 12 00:00:00 UTC 2022

The immune landscape of human thymic epithelial tumors.

Nature communications

Xin Z,Lin M,Hao Z,Chen D,Chen Y,Chen X,Xu X,Li J,Wu D,Chai Y,Wu P

Sat Sep 17 00:00:00 UTC 2022

Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.

Journal of clinical laboratory analysis

Zhang Y,Li Y,Li F,Li L,Wang C,Wang H,Chen Y,Zhang C,Zhang Y,Wang W

Thu Dec 01 00:00:00 UTC 2022

Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.

Journal of clinical laboratory analysis

Zhang Y,Li Y,Li F,Li L,Wang C,Wang H,Chen Y,Zhang C,Zhang Y,Wang W

Thu Dec 01 00:00:00 UTC 2022

Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3.

Biochemical and biophysical research communications

Li ZX,Yang DJ,Huo ZK,Wen PH,Hu BW,Wang ZH,Guo WZ,Zhang SJ

Fri May 07 00:00:00 UTC 2021

Effects of chitinase-3-like protein 1 on brain death-induced hepatocyte apoptosis via PAR2-JNK-caspase-3.

Biochemical and biophysical research communications

Li ZX,Yang DJ,Huo ZK,Wen PH,Hu BW,Wang ZH,Guo WZ,Zhang SJ

Fri May 07 00:00:00 UTC 2021

MIN score predicts primary response to infliximab/adalimumab and vedolizumab therapy in patients with inflammatory bowel diseases.

Genomics

Shi Y,He W,Zhong M,Yu M

Thu Jul 01 00:00:00 UTC 2021

Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

eLife

Shan Z,Li L,Atkins CL,Wang M,Wen Y,Jeong J,Moreno NF,Feng D,Gui X,Zhang N,Lee CG,Elias JA,Lee WM,Gao B,Lam FW,An Z,Ju C

Thu Jun 10 00:00:00 UTC 2021

Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

eLife

Shan Z,Li L,Atkins CL,Wang M,Wen Y,Jeong J,Moreno NF,Feng D,Gui X,Zhang N,Lee CG,Elias JA,Lee WM,Gao B,Lam FW,An Z,Ju C

Thu Jun 10 00:00:00 UTC 2021

Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

eLife

Shan Z,Li L,Atkins CL,Wang M,Wen Y,Jeong J,Moreno NF,Feng D,Gui X,Zhang N,Lee CG,Elias JA,Lee WM,Gao B,Lam FW,An Z,Ju C

Thu Jun 10 00:00:00 UTC 2021

BYSL Promotes Glioblastoma Cell Migration, Invasion, and Mesenchymal Transition Through the GSK-3β/β-Catenin Signaling Pathway.

Frontiers in oncology

Sha Z,Zhou J,Wu Y,Zhang T,Li C,Meng Q,Musunuru PP,You F,Wu Y,Yu R,Gao S

Fri Nov 13 00:00:00 UTC 2020

LINC00963 Promotes Ovarian Cancer Proliferation, Migration and EMT via the miR-378g /CHI3L1 Axis.

Cancer management and research

Liu W,Yang YJ,An Q

Mon Jan 29 00:00:00 UTC 2024

SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex.

Glia

Brøchner CB,Møllgård K

Fri Jan 01 00:00:00 UTC 2016

SSEA-4 and YKL-40 positive progenitor subtypes in the subventricular zone of developing human neocortex.

Glia

Brøchner CB,Møllgård K

Fri Jan 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 39 kDa synovial protein; Breast regression protein 39; BRP39 protein; Cartilage glycoprotein 39; CGP-39; CGP39; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); Chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; hCGP39; YKL-40

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Gene Aliases: ASRT7; AW208766; Brp39; CGP-39; CHI3L1; Chil1; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YKL-40; YKL40; YYL-40

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UniProt ID: (Human) P36222, (Mouse) Q61362

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Entrez Gene ID: (Human) 1116, (Mouse) 12654

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Function(s)

chitinase activity extracellular matrix structural constituent chitin binding carbohydrate binding hydrolase activity, hydrolyzing O-glycosyl compounds

Process(es)

carbohydrate metabolic process chitin catabolic process apoptotic process inflammatory response activation of NF-kappaB-inducing kinase activity positive regulation of peptidyl-threonine phosphorylation lung development positive regulation of angiogenesis positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade interleukin-8 secretion response to mechanical stimulus response to tumor necrosis factor cartilage development response to interleukin-1 response to interleukin-6 cellular response to interleukin-1 cellular response to tumor necrosis factor

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CHI3L1 Polyclonal Antibody

CHI3L1 Antibody (12036-1-AP) in IHC (P)

Product Details

12036-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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