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Invitrogen
CHIL3 Monoclonal Antibody (281926)
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FIGURE: 1 / 1
CHIL3 Antibody (MA5-23981) in WB
Western blot analysis of CHIL3 in mouse bone marrow. Samples were incubated in CHIL3 monoclonal antibody (Product # MA5-23981) using a dilution of 0.5 µg/mL followed by a HRP-conjugated Anti-Rat IgG secondary antibody. A specific band was detected for YM1/Chitinase 3-like 3 at approximately 45 kDa (as indicated). This experiment was conducted under reducing conditions.
Product Details
MA5-23981
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
281926
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Chitinase 3-like 3/ECF-L Tyr22-Tyr398
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610311
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The CHIL3 gene encodes the protein chitinase-like 3, which is primarily secreted by macrophages and is involved in immune regulation, tissue remodeling, and inflammatory responses. CHIL3, also known as Ym1, belongs to the chitinase-like protein family but lacks chitinase activity due to mutations in its catalytic domain. It is predominantly expressed in lung tissue, where it plays a vital role in asthmatic responses and allergic inflammation. Furthermore, CHIL3 exerts anti-inflammatory roles during pathogen infection by modulating macrophage pro-inflammatory activity and promoting the Th2 immune response. Beyond immunological involvement, CHIL3 is integral to tissue repair mechanisms and cancer cell proliferation, contributing to extracellular matrix restructuring and angiogenesis. It facilitates macrophage polarization towards an M2 phenotype, which is associated with tumor progression and metastasis. Thus, CHIL3 is considered a potential biomarker for inflammatory diseases and cancer, with ongoing research examining its therapeutic modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-N-acetylhexosaminidase Ym1; chitinase 3-like 3; Chitinase-3-like protein 3; Chitinase-like protein 3; ECF-L; Eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; Secreted protein Ym1
Gene Aliases: AI505981; Chi3l3; Chil3; ECF-L; Ym1
UniProt ID: (Mouse) O35744
Entrez Gene ID: (Mouse) 12655
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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