Bioss

CHMP4B+CHMP4C Polyclonal Antibody

View all (2) CHMP4B/C antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-7744R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Charged multivesicular body protein 4b; Charged multivesicular body protein 4c; CHMP4b; CHMP4c; chromatin modifying protein 4B; chromatin modifying protein 4C; Chromatin-modifying protein 4b; Chromatin-modifying protein 4c; hSnf7-2; hSnf7-3; hVps32-2; hVps32-3; SNF7 homolog associated with Alix 1; SNF7 homolog associated with Alix 3; Snf7 homologue associated with Alix 1; Snf7 homologue associated with Alix 3; SNF7-2; SNF7-3; Vacuolar protein sorting-associated protein 32-2; Vacuolar protein sorting-associated protein 32-3; vacuolar protein-sorting-associated protein 32-2; Vps32-2; Vps32-3

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Gene Aliases: 2010012F05Rik; 2010012P02Rik; 2210015K02Rik; 2310010I16Rik; C20orf178; C76846; CHMP4A; CHMP4B; CHMP4C; CTPP3; CTRCT31; dJ553F4.4; RGD1309846; RGD1565889; SHAX1; SHAX3; SNF7; SNF7-2; SNF7-3; Vps32-2; VPS32B; VPS32C

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UniProt ID: (Human) Q9H444, (Human) Q96CF2, (Mouse) Q9D8B3, (Mouse) Q9D7F7, (Rat) Q569C1

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Entrez Gene ID: (Human) 128866, (Human) 92421, (Mouse) 75608, (Rat) 100359642, (Mouse) 66371, (Rat) 361916

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