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OriGene
CHMP5 Monoclonal Antibody (OTI2E6), TrueMAB™
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FIGURE: 1 / 5
CHMP5 Antibody (CF808543) in IHC (P)
Immunohistochemical staining of paraffin-embedded human prostate tissue within the normal limits using anti-CHMP5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808543)(1:150)
Product Details
CF808543
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2E6
Immunogen
Full length human recombinant protein of human CHMP5 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein PNAS-2; Charged multivesicular body protein 5; chromatin modifying protein 5; Chromatin-modifying protein 5; HGNC:26942; hVps60; likely ortholog of H. sapiens SNF7 domain containing 2; SNF7 domain containing 2; SNF7 domain-containing protein 2; Vacuolar protein sorting-associated protein 60; Vps60
Gene Aliases: 2210412K09Rik; AW545668; C9orf83; CGI-34; CHMP5; HSPC177; PNAS-114; PNAS-2; RGD1305968; SNF7DC2; Vps60
UniProt ID: (Human) Q9NZZ3, (Mouse) Q9D7S9, (Rat) Q4QQV8
Entrez Gene ID: (Human) 51510, (Mouse) 76959, (Rat) 297995
cell separation after cytokinesis
regulation of receptor recycling
nucleus organization
lysosome organization
mitotic metaphase plate congression
endosome to lysosome transport
regulation of centrosome duplication
protein transport
endosomal transport
viral life cycle
multivesicular body assembly
viral budding
multivesicular body sorting pathway
cell-cell adhesion
regulation of mitotic spindle assembly
ESCRT III complex disassembly
transport
vacuolar transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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