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FIGURE: 1 / 1
CHRM2 Antibody (PA5-86501) in WB
Western blot analysis of CHRM2 in Lane 1: CT26 whole cell lysate (40 µg), Lane 2: PC12 whole cell lysate (40 µg), Lane 3: HeLa whole cell lysate (40 µg), Lane 4: SGC7901 whole cell lysate (40 µg), Lane 5: HEK293T whole cell lysate (40 µg). Sample was incubated with CHRM2 polyclonal antibody (Product # PA5-86501) using a 1:1000 dilution.
Product Details
PA5-86501
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 191-240 of Human mAChR M2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2803278
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2 muscarinic acetylcholine receptor; M2-mAChR; m2AChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor; muscarinic receptor m2
Gene Aliases: AChR-M2; Acm2; Chrm-2; CHRM2; HM2; M2
UniProt ID: (Human) P08172, (Mouse) Q9ERZ4, (Rat) P10980
Entrez Gene ID: (Human) 1129, (Mouse) 243764, (Rat) 81645
regulation of smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
chemical synaptic transmission
synaptic transmission, cholinergic
sensory perception of chemical stimulus
regulation of heart contraction
response to virus
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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