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Invitrogen
CHRNA3 Polyclonal Antibody
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Product Details
PA5-28258
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Extracellular domain of human Nicotinic Acetylcholine Receptor alpha 3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2545734
Product Specific Information
Recommended positive controls: Molt-4.
Predicted reactivity: Mouse (94%), Rat (94%), Chicken (87%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CHRNA3 locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylcholine receptor; cholinergic receptor; cholinergic receptor, nicotinic alpha 3; cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; nAChR alpha 3; Neuronal acetylcholine receptor subunit alpha-3; neuronal nicotinic acetylcholine receptor, alpha3 subunit
Gene Aliases: CHRNA3; LNCR2; NACHRA3; PAOD2
UniProt ID: (Human) P32297
Entrez Gene ID: (Human) 1136
ion transport
regulation of smooth muscle contraction
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
synaptic transmission, cholinergic
nervous system development
heart development
locomotory behavior
response to inorganic substance
regulation of acetylcholine secretion, neurotransmission
behavioral response to nicotine
regulation of membrane potential
response to drug
regulation of dendrite morphogenesis
protein heterooligomerization
excitatory postsynaptic potential
synaptic transmission involved in micturition
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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