OriGene

CIB1 Monoclonal Antibody (OTI1B8), TrueMAB™

View all (18) Calmyrin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF811147

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI1B8

Immunogen

Human recombinant protein fragment corresponding to amino acids 2-191 of human CIB1 produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alphabeta, which may implicate this protein as a regulatory molecule for alphabeta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: calcium and integrin binding 1 (calmyrin); calcium and integrin binding, protein kinase interacting protein; Calcium and integrin-binding protein 1; Calcium- and integrin-binding protein; Calmyrin; CIB; CIBP; DNA-dependent protein kinase interacting protein; DNA-PK interaction protein; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; protein kinase, DNA activated, catalytic polypeptide interacting protein; SIP2-28; SNK-interacting protein 2-28; testicular secretory protein Li 9

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Gene Aliases: CIB; CIB1; Cibkip; CIBP; KIP; KIP1; PRKDCIP; SIP2-28

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UniProt ID: (Human) Q99828, (Rat) Q9R010, (Mouse) Q9Z0F4

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Entrez Gene ID: (Human) 10519, (Rat) 81823, (Mouse) 23991

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Function(s)
calcium ion binding protein binding protein C-terminus binding calcium-dependent protein kinase inhibitor activity Ras GTPase binding protein kinase binding protein serine/threonine kinase inhibitor activity protein anchor ion channel binding metal ion binding
Process(es)
angiogenesis negative regulation of protein phosphorylation positive regulation of protein phosphorylation positive regulation of cell-matrix adhesion response to ischemia double-strand break repair apoptotic process cellular response to DNA damage stimulus negative regulation of microtubule depolymerization endomitotic cell cycle cell adhesion spermatid development positive regulation of cell proliferation negative regulation of cell proliferation negative regulation of neuron projection development platelet formation positive regulation of cell growth positive regulation of cell migration cytoplasmic microtubule organization positive regulation of cell adhesion mediated by integrin thrombopoietin-mediated signaling pathway regulation of cell proliferation negative regulation of apoptotic process positive regulation of catalytic activity negative regulation of megakaryocyte differentiation positive regulation of NF-kappaB transcription factor activity cell division regulation of cell division negative regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to tumor necrosis factor cellular response to growth factor stimulus negative regulation of protein serine/threonine kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of establishment of protein localization to plasma membrane positive regulation of cell migration involved in sprouting angiogenesis positive regulation of protein targeting to membrane extrinsic apoptotic signaling pathway positive regulation of substrate adhesion-dependent cell spreading cellular response to nerve growth factor stimulus positive regulation of male germ cell proliferation negative regulation of protein kinase activity cell cycle spermatogenesis cell differentiation
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