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Invitrogen
CIRBP Polyclonal Antibody
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FIGURE: 1 / 3
CIRBP Antibody (PA5-31661) in ICC/IF
CIRBP Polyclonal Antibody detects CIRBP protein at nucleus by immunofluorescent analysis. Sample: A549 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CIRBP protein stained by CIRBP Polyclonal Antibody (Product # PA5-31661) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 µm.
Product Details
PA5-31661
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human CIRBP. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.67 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549134
Product Specific Information
Recommended positive controls: HCT116.
Predicted reactivity: Mouse (94%), Rat (94%), Chicken (94%), Rhesus Monkey (100%), Chimpanzee (96%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor and promotes assembly of stress granules (SGs), when overexpressed.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A18 hnRNP; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
Gene Aliases: A18HNRNP; CIRBP; CIRP
UniProt ID: (Human) Q14011
Entrez Gene ID: (Human) 1153
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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