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Product Details
H00004435-M04
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
6E12
Immunogen
CITED1 (NP_004134, 94 a.a. approximately 193 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: SMQLQKLNSQ YQGMAAATPG QPGEAGPLQN WDFGAQAGGA ESLSPSAGAQ SPAIIDSDPV DEEVLMSLVV ELGLDRANEL PELWLGQNEF DFTADFPSSC
Target Information
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbp/p300-interacting transactivator 1; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 1; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1; melanocyte-specific gene 1; melanocyte-specific gene 1 protein; Melanocyte-specific protein 1
Gene Aliases: CITED1; MSG1
UniProt ID: (Human) Q99966
Entrez Gene ID: (Human) 4435, (Rat) 64466
RNA polymerase II transcription coactivator activity
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
protein C-terminus binding
protein homodimerization activity
transcription regulatory region DNA binding
LBD domain binding
co-SMAD binding
embryonic axis specification
vasculogenesis
branching involved in ureteric bud morphogenesis
kidney development
placenta development
morphogenesis of an epithelium
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
regulation of transcription, DNA-templated
nucleocytoplasmic transport
transforming growth factor beta receptor signaling pathway
brain development
positive regulation of gene expression
melanocyte differentiation
response to lipopolysaccharide
response to insulin
response to cytokine
response to interferon-gamma
melanin biosynthetic process
pigmentation
negative regulation of neuron apoptotic process
response to estrogen
negative regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
response to cAMP
SMAD protein signal transduction
labyrinthine layer development
spongiotrophoblast layer development
response to interleukin-1
response to interleukin-2
response to interleukin-4
response to interleukin-6
response to interleukin-9
response to interleukin-11
response to parathyroid hormone
response to transforming growth factor beta
metanephros development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
cell proliferation
negative regulation of Wnt signaling pathway
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
mesenchymal to epithelial transition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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