Invitrogen

CITED2 Monoclonal Antibody (JA22)

1 Reference
View all (9) CITED2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA3-16523

Applications
Tested Dilution
Publications

Western Blot (WB)

2 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

JA22

Immunogen

Human CITED 2 protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2276266

Product Specific Information

Suggested positive control: Hela whole cell extract.

Target Information

The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cbp/p300-interacting transactivator 2; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; melanocyte specific gene 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj

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Gene Aliases: AI835299; ASD8; CITED2; ER154-like; MRG-1; MRG1; Msg2; P35SRJ; VSD2

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UniProt ID: (Human) Q99967, (Mouse) O35740

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Entrez Gene ID: (Human) 10370, (Mouse) 17684

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Function(s)
RNA polymerase II transcription coactivator activity RNA polymerase II transcription corepressor activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity transcription corepressor activity protein binding histone acetyltransferase binding LBD domain binding RNA polymerase II activating transcription factor binding transcription cofactor activity SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter response to hypoxia liver development outflow tract morphogenesis regulation of organ formation transcription, DNA-templated determination of left/right symmetry heart development sex determination cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell-cell adhesion cell differentiation negative regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway response to fluid shear stress positive regulation of peroxisome proliferator activated receptor signaling pathway adrenal cortex formation negative regulation of apoptotic process response to estrogen positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development ventricular septum morphogenesis embryonic heart tube left/right pattern formation left/right pattern formation negative regulation of transcription from RNA polymerase II promoter in response to hypoxia left/right axis specification nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry positive regulation of male gonad development blood vessel development vasculogenesis branching involved in ureteric bud morphogenesis in utero embryonic development kidney development trophectodermal cell differentiation neural tube formation neural tube closure embryonic placenta development vasculature development heart looping morphogenesis of an epithelium lens morphogenesis in camera-type eye hematopoietic progenitor cell differentiation leukocyte differentiation endocardial cushion development ventricular septum development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway multicellular organism development central nervous system development peripheral nervous system development male gonad development cranial nerve morphogenesis adrenal gland development granulocyte differentiation skeletal muscle cell differentiation decidualization thymus development embryonic camera-type eye morphogenesis erythrocyte development embryonic process involved in female pregnancy bone morphogenesis cardiac septum morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in heart development determination of heart left/right asymmetry regulation of nucleic acid-templated transcription
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