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Invitrogen
CKMT1A Polyclonal Antibody
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FIGURE: 1 / 3
CKMT1A Antibody (PA5-106347) in ICC/IF
Immunofluorescent analysis of CKMT1A in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CKMT1A polyclonal antibody (Product # PA5-106347) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Product Details
PA5-106347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CKMT1A; CKMT1B(Accession P12532), corresponding to amino acid residues F30-T80.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854023
Product Specific Information
Antibody detects endogenous levels of total CKMT1A.
Target Information
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acidic-type mitochondrial creatine kinase; Creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1 (ubiquitous); creatine kinase, mitochondrial 1, ubiquitous; Mia-CK; U-MtCK; Ubiquitous mitochondrial creatine kinase
Gene Aliases: CKMT; CKMT1; CKMT1A; CKMT1B; mi-CK; mia-CK; Mt-CK; ScCKmit; U-MtCK; UbCKmit
UniProt ID: (Human) P12532, (Mouse) P30275
Entrez Gene ID: (Human) 548596, (Mouse) 12716, (Rat) 29593
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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