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Invitrogen
CLCN1 Polyclonal Antibody
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CLCN1 Antibody (PA5-109549) in IHC (P)
Immunohistochemistry analysis of CLCN1 in paraffin-embedded mouse skeletal muscle. Samples were incubated with CLCN1 Polyclonal antibody (Product # PA5-109549) using a dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-109549
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 779-988 of human CLCN1 (NP_0000743)
Conjugate
Form
Liquid
Concentration
1.42 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854960
Product Specific Information
Immunogen sequence: ARPTKKKTTQ DSTDLVDNMS PEEIEAWEQE QLSQPVCFDS CCIDQSPFQL VEQTTLHKTH TLFSLLGLHL AYVTSMGKLR GVLALEELQK AIEGHTKSGV QLRPPLASFR NTTSTRKSTG APPSSAENWN LPEDRPGATG TGDVIAASPE TPVPSPSPEP PLSLAPGKVE GELEELELVE SPGLEEELAD ILQGPSLRST DEEDEDELIL
Target Information
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. CLC1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC6 and CLC7 are broadly expressed in several tissues including testis, kidney, brain and muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arrested development of righting response; chloride channel 1, skeletal muscle; Chloride channel protein 1; Chloride channel protein, skeletal muscle; chloride channel, voltage-sensitive 1; CIC 1; CIC1; ClC-1; MGC138361; MGC142055
Gene Aliases: adr; Clc-1; CLC1; CLCN1; mto; myotonia; nmf355; SMCC; SMCC1
UniProt ID: (Human) P35523, (Mouse) Q64347, (Rat) P35524
Entrez Gene ID: (Human) 1180, (Mouse) 12723, (Rat) 25688
transport
ion transport
chloride transport
neuronal action potential propagation
regulation of ion transmembrane transport
transmembrane transport
chloride transmembrane transport
regulation of anion transmembrane transport
ion transmembrane transport
regulation of anion transport
muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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