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Invitrogen
CLCN2 Polyclonal Antibody
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CLCN2 Antibody (PA5-96510) in WB
Western blot analysis of CLCN2 in extracts of various cell lines. Samples were incubated with CLCN2 Polyclonal antibody (Product # PA5-96510) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96510
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 550-770 of human CLCN2 (NP_0011645601)
Conjugate
Form
Liquid
Concentration
2.11 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808312
Product Specific Information
Immunogen sequence: PSLYDSIIRI KKLPYLPELG WGRHQQYRVR VEDIMVRDVP HVALSCTFRD LRLALHRTKG RMLALVESPE SMILLGSIER SQVVALLGAQ LSPARRRQHM QERRATQTSP LSDQEGPPTP EASVCFQVNT EDSAFPAARG ETHKPLKPAL KRGPSVTRNL GESPTGSAES AGIALRSLFC GSPPPEAASE KLESCEKRKL KRVRISLASD ADLEGEMSPE E
Positive Samples: Mouse brain, Mouse testis; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
The transmembrane protein encoded by this gene is a voltage-gated chloride channel that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chloride channel 2; Chloride channel protein 2; chloride channel, voltage-sensitive 2; CIC 2; CIC2; ClC-2; EG13
Gene Aliases: AL118368; CIC-2; ClC-2; CLC2; CLCN2; ECA2; ECA3; EGI11; EGI3; EGMA; EJM6; EJM8; LKPAT; nmf240
UniProt ID: (Human) P51788, (Mouse) Q9R0A1
Entrez Gene ID: (Human) 1181, (Mouse) 12724
transport
ion transport
chloride transport
regulation of ion transmembrane transport
transmembrane transport
retina development in camera-type eye
cell differentiation involved in salivary gland development
chloride transmembrane transport
regulation of anion transmembrane transport
ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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