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Proteintech
CLDN16 Polyclonal Antibody
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Product Details
27638-1-AP
Product Specifications
Species Reactivity
Dog,
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CLDN16 Fusion Protein Ag26531 (1-73 aa encoded by BC069682)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTSRTPLLV TACLYYSYCN SRHLQQGVRK SKRPVFSHCQ VPETQKTDTR HLSGARAGVC PCCHPDGLLA TMRD (1-73 aa encoded by BC069682)
Target Information
Tight junction group of proteins are a cell-to-cell adhesion structure in epithelial cells that constitute the epithelial junctional complex with adherens junctions and desmosomes. Tight junction strands are mainly composed of claudins, occludin, and JAM. Claudin-16 belongs to the Claudin family of protein which is composed of 23 integral membrane proteins. Claudins are responsible for the formation of tight junction strands and are connected with the actin cytoskeleton mediated by ZO-1. Claudin 16, also known as Paracellin-1, is a renal tight junction protein required for paracellular magnesium resorption. It is localized in the intercellular junctions of the epithelial cells of the thick ascending limb of Henle's loop (a TAL marker) are used to localize this specific structure of nephrons in kidney sections. Mg2+ resorption occurs in TAL, and Claudin-16 is required for this paracellular function. Failure in renal 'handling' of magnesium can result in hypermagnesemia, whose major direct toxicity implications are cardiovascular as well as renal failure. Recent studies have shown that the lack of Claudin-16 proteins contributes to the dysfunction of paracellular renal transport systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Claudin-16; hypomagnesemia 3, with hypercalciuria and nephrocalcinosis; Paracellin-1; PCLN-1
Gene Aliases: CLDN16; HOMG3; PCLN1
UniProt ID: (Human) Q9Y5I7
Entrez Gene ID: (Human) 10686, (Dog) 608218
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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