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Invitrogen
CLIP1 Recombinant Rabbit Monoclonal Antibody (23GB3080)
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FIGURE: 1 / 4
CLIP1 Antibody (MA5-53324) in ICC/IF
Immunocytochemistry analysis of CLIP1 in HepG2 cells. Nuclei were stained blue with DAPI; CLIP1 recombinant monoclonal antibody (Product # MA5-53324) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
Product Details
MA5-53324
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB3080
Immunogen
A synthesized peptide derived from CLIP170 (1400-1438AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3247797
Target Information
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAP-Gly domain-containing linker protein 1; Clip 170; CLIP-170; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170; Cytoplasmic linker protein 170 alpha-2; cytoplasmic linker protein 50; cytoplasmic linker protein CLIP-170; MGC131604; Reed-Steinberg cell-espressed intermediate filament-associated protein; Reed-Sternberg intermediate filament-associated protein; Restin; restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Gene Aliases: 1110007I12Rik; 4631429H07Rik; AV017631; C81039; CLIP; CLIP-170; CLIP1; CLIP170; Clip50; CYLN1; Kiaa4046; mKIAA4046; restin; RSN
UniProt ID: (Human) P30622, (Mouse) Q922J3
Entrez Gene ID: (Human) 6249, (Mouse) 56430
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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