Product References
Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR in Caenorhabditis elegans.
Theranostics
Cong W,Wang Y,Yuan C,Xu M,Wang H,Hu Y,Dai X,Weng Y,Timashev P,Liang XJ,Huang Y
Mon Jun 26 00:00:00 UTC 2023
Balanced mitochondrial and cytosolic translatomes underlie the biogenesis of human respiratory complexes.
Genome biology
Soto I,Couvillion M,Hansen KG,McShane E,Moran JC,Barrientos A,Churchman LS
Tue Aug 09 00:00:00 UTC 2022
Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength.
Nature communications
Xu Z,Fu T,Guo Q,Zhou D,Sun W,Zhou Z,Chen X,Zhang J,Liu L,Xiao L,Yin Y,Jia Y,Pang E,Chen Y,Pan X,Fang L,Zhu MS,Fei W,Lu B,Gan Z
Wed Feb 16 00:00:00 UTC 2022
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy.
Human molecular genetics
Liang M,Ji Y,Zhang L,Wang X,Hu C,Zhang J,Zhu Y,Mo JQ,Guan MX
Thu Sep 29 00:00:00 UTC 2022
Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism.
Nature communications
Bussi C,Heunis T,Pellegrino E,Bernard EM,Bah N,Dos Santos MS,Santucci P,Aylan B,Rodgers A,Fearns A,Mitschke J,Moore C,MacRae JI,Greco M,Reinheckel T,Trost M,Gutierrez MG
Mon Nov 28 00:00:00 UTC 2022
KPNB1 modulates the Machado-Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP.
Cellular and molecular life sciences : CMLS
Abeditashi M,Weber JJ,Pereira Sena P,Velic A,Kalimeri M,Incebacak Eltemur RD,Schmidt J,Hübener-Schmid J,Hauser S,Macek B,Riess O,Schmidt T
Wed Jul 06 00:00:00 UTC 2022
Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4.
Science advances
Guo Q,Xu Z,Zhou D,Fu T,Wang W,Sun W,Xiao L,Liu L,Ding C,Yin Y,Zhou Z,Sun Z,Zhu Y,Zhou W,Jia Y,Xue J,Chen Y,Chen XW,Piao HL,Lu B,Gan Z
Fri Jul 29 00:00:00 UTC 2022
CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2.
Cells
Key J,Gispert S,Koornneef L,Sleddens-Linkels E,Kohli A,Torres-Odio S,Koepf G,Amr S,Reichlmeir M,Harter PN,West AP,Münch C,Baarends WM,Auburger G
Thu Dec 22 00:00:00 UTC 2022
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination.
The Journal of cell biology
Oshima Y,Cartier E,Boyman L,Verhoeven N,Polster BM,Huang W,Kane M,Lederer WJ,Karbowski M
Mon Jun 07 00:00:00 UTC 2021
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Journal of immunology (Baltimore, Md. : 1950)
Torres-Odio S,Lei Y,Gispert S,Maletzko A,Key J,Menissy SS,Wittig I,Auburger G,West AP
Thu Apr 15 00:00:00 UTC 2021
SIRT3-mediated mitochondrial unfolded protein response weakens breast cancer sensitivity to cisplatin.
Genes & genomics
Chen H,Zhang DM,Zhang ZP,Li MZ,Wu HF
Wed Dec 01 00:00:00 UTC 2021
Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation.
The Journal of biological chemistry
Pollecker K,Sylvester M,Voos W
Fri Oct 01 00:00:00 UTC 2021
Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses.
Human molecular genetics
Straub IR,Weraarpachai W,Shoubridge EA
Mon May 17 00:00:00 UTC 2021
Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.
Nature communications
Della-Flora Nunes G,Wilson ER,Marziali LN,Hurley E,Silvestri N,He B,O'Malley BW,Beirowski B,Poitelon Y,Wrabetz L,Feltri ML
Wed Jun 02 00:00:00 UTC 2021
Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse.
Neurogenetics
Maletzko A,Key J,Wittig I,Gispert S,Koepf G,Canet-Pons J,Torres-Odio S,West AP,Auburger G
Fri Oct 01 00:00:00 UTC 2021
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Cellular and molecular gastroenterology and hepatology
Sun D,Niu Z,Zheng HX,Wu F,Jiang L,Han TQ,Wei Y,Wang J,Jin L
Mon Mar 07 00:00:00 UTC 2022
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
The Journal of biological chemistry
Jin X,Zhang Z,Nie Z,Wang C,Meng F,Yi Q,Chen M,Sun J,Zou J,Jiang P,Guan MX
Mon Aug 02 00:00:00 UTC 2021
Mitochondrial DNA Haplogroup M7 Confers Disability in a Chinese Aging Population.
Frontiers in genetics
Sun D,Yao S,Wu F,Deng W,Ma Y,Jin L,Wang J,Wang X
Tue Nov 17 00:00:00 UTC 2020
Nicotinamide Riboside Enhances Mitochondrial Proteostasis and Adult Neurogenesis through Activation of Mitochondrial Unfolded Protein Response Signaling in the Brain of ALS SOD1G93A Mice.
International journal of biological sciences
Zhou Q,Zhu L,Qiu W,Liu Y,Yang F,Chen W,Xu R
Mon Nov 02 00:00:00 UTC 2020
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation.
The Journal of biological chemistry
Gong S,Wang X,Meng F,Cui L,Yi Q,Zhao Q,Cang X,Cai Z,Mo JQ,Liang Y,Guan MX
Fri Jan 24 00:00:00 UTC 2020
Mutant huntingtin does not cross the mitochondrial outer membrane.
Human molecular genetics
Hamilton J,Brustovetsky T,Khanna R,Brustovetsky N
Sat Oct 10 00:00:00 UTC 2020
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Bioengineered
You H,Jin Y,Kang J,Mao Y,Su J,Sun L,Wang L,Meng H
Tue Dec 01 00:00:00 UTC 2020
Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis.
iScience
Zhang R,Wang X,Qu JH,Liu B,Zhang P,Zhang T,Fan PC,Wang XM,Xiao GY,Su Y,Xie Y,Liu Y,Pei JF,Zhang ZQ,Hao DL,Xu P,Chen HZ,Liu DP
Fri Jul 26 00:00:00 UTC 2019
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Nucleic acids research
Chen D,Zhang Z,Chen C,Yao S,Yang Q,Li F,He X,Ai C,Wang M,Guan MX
Tue Jun 04 00:00:00 UTC 2019
Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions.
Cell metabolism
Forsström S,Jackson CB,Carroll CJ,Kuronen M,Pirinen E,Pradhan S,Marmyleva A,Auranen M,Kleine IM,Khan NA,Roivainen A,Marjamäki P,Liljenbäck H,Wang L,Battersby BJ,Richter U,Velagapudi V,Nikkanen J,Euro L,Suomalainen A
Tue Dec 03 00:00:00 UTC 2019
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
PLoS genetics
Wang P,Deng J,Dong J,Liu J,Bigio EH,Mesulam M,Wang T,Sun L,Wang L,Lee AY,McGee WA,Chen X,Fushimi K,Zhu L,Wu JY
Wed May 01 00:00:00 UTC 2019
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Cell reports
Jian F,Chen D,Chen L,Yan C,Lu B,Zhu Y,Chen S,Shi A,Chan DC,Song Z
Tue Jun 05 00:00:00 UTC 2018
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Cell reports
Jian F,Chen D,Chen L,Yan C,Lu B,Zhu Y,Chen S,Shi A,Chan DC,Song Z
Tue Jun 05 00:00:00 UTC 2018
LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.
Molecular and cellular biology
Zurita Rendón O,Shoubridge EA
Mon Oct 15 00:00:00 UTC 2018
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.
Cell metabolism
Khan NA,Nikkanen J,Yatsuga S,Jackson C,Wang L,Pradhan S,Kivelä R,Pessia A,Velagapudi V,Suomalainen A
Tue Aug 01 00:00:00 UTC 2017
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.
Cell metabolism
Khan NA,Nikkanen J,Yatsuga S,Jackson C,Wang L,Pradhan S,Kivelä R,Pessia A,Velagapudi V,Suomalainen A
Tue Aug 01 00:00:00 UTC 2017
Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.
Molecular metabolism
Ost M,Coleman V,Voigt A,van Schothorst EM,Keipert S,van der Stelt I,Ringel S,Graja A,Ambrosi T,Kipp AP,Jastroch M,Schulz TJ,Keijer J,Klaus S
Mon Feb 01 00:00:00 UTC 2016
Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.
Molecular metabolism
Ost M,Coleman V,Voigt A,van Schothorst EM,Keipert S,van der Stelt I,Ringel S,Graja A,Ambrosi T,Kipp AP,Jastroch M,Schulz TJ,Keijer J,Klaus S
Mon Feb 01 00:00:00 UTC 2016
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
The Journal of cell biology
Richter U,Lahtinen T,Marttinen P,Suomi F,Battersby BJ
Mon Oct 26 00:00:00 UTC 2015
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
The Journal of cell biology
Richter U,Lahtinen T,Marttinen P,Suomi F,Battersby BJ
Mon Oct 26 00:00:00 UTC 2015
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Cell metabolism
Mishra P,Carelli V,Manfredi G,Chan DC
Tue Apr 01 00:00:00 UTC 2014
Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.
Cell metabolism
Mishra P,Carelli V,Manfredi G,Chan DC
Tue Apr 01 00:00:00 UTC 2014
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.
EMBO molecular medicine
Khan NA,Auranen M,Paetau I,Pirinen E,Euro L,Forsström S,Pasila L,Velagapudi V,Carroll CJ,Auwerx J,Suomalainen A
Sun Jun 01 00:00:00 UTC 2014
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.
EMBO molecular medicine
Khan NA,Auranen M,Paetau I,Pirinen E,Euro L,Forsström S,Pasila L,Velagapudi V,Carroll CJ,Auwerx J,Suomalainen A
Sun Jun 01 00:00:00 UTC 2014
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Human molecular genetics
Gispert S,Parganlija D,Klinkenberg M,Dröse S,Wittig I,Mittelbronn M,Grzmil P,Koob S,Hamann A,Walter M,Büchel F,Adler T,Hrabé de Angelis M,Busch DH,Zell A,Reichert AS,Brandt U,Osiewacz HD,Jendrach M,Auburger G
Sun Dec 15 00:00:00 UTC 2013
Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors.
Human molecular genetics
Gispert S,Parganlija D,Klinkenberg M,Dröse S,Wittig I,Mittelbronn M,Grzmil P,Koob S,Hamann A,Walter M,Büchel F,Adler T,Hrabé de Angelis M,Busch DH,Zell A,Reichert AS,Brandt U,Osiewacz HD,Jendrach M,Auburger G
Sun Dec 15 00:00:00 UTC 2013
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
PloS one
Moore F,Santin I,Nogueira TC,Gurzov EN,Marselli L,Marchetti P,Eizirik DL
Tue Jul 31 00:00:00 UTC 2012
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
PloS one
Moore F,Santin I,Nogueira TC,Gurzov EN,Marselli L,Marchetti P,Eizirik DL
Tue Jul 31 00:00:00 UTC 2012
