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Invitrogen
CLSTN1 Polyclonal Antibody
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FIGURE: 1 / 1
CLSTN1 Antibody (PA5-109556) in WB
Western blot analysis of CLSTN1 in extracts of various cell lines. Samples were incubated with CLSTN1 Polyclonal antibody (Product # PA5-109556) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-109556
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-350 of human CLSTN1 (NP_055759.3).
Conjugate
Form
Liquid
Concentration
2.04 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854967
Product Specific Information
Immunogen sequence: ARVNKHKPWL EPTYHGIVTE NDNTVLLDPP LIALDKDAPL RFAGEICGFK IHGQNVPFDA VVVDKSTGEG VIRSKEKLDC ELQKDYSFTI QAYDCGKGPD GTNVKKSHKA TVHIQVNDVN EYAPVFKEKS YKATVIEGKQ YDSILRVEAV DADCSPQFSQ ICSYEIITPD VPFTVDKDGY IKNTEKLNYG KEHQYKLTVT AYDCGKKRAT EDVLVKISIK PTCTPGWQGW NNRIEYEPGT GALAVFPNIH LETCDEPVAS VQATVELETS HIGKGCDRDT YSEKSLHRLC GAAAGTAELL PSPSGSLNWT MGLPTDNGHD SD
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alc-alpha; alcadein alpha; Alcadein-alpha; Calsyntenin-1; FLJ32258
Gene Aliases: 1810034E21Rik; Clstn1; Cs1; Cst-1; Cstn1; Kiaa0911
UniProt ID: (Rat) Q6Q0N0, (Mouse) Q9EPL2
Entrez Gene ID: (Rat) 313717, (Mouse) 65945
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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