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Invitrogen
CMKLR1 Polyclonal Antibody
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FIGURE: 1 / 4
CMKLR1 Antibody (PA5-50932) in ICC/IF
Frontiers in endocrinology 2021 -
Figure 2 Identification of RvE1's receptor on cumulus cells (CCs) and oocytes. (A) Detection of ChemR23 expression on CCs by western blot. THP-1 as a positive control; beta-actin as the internal reference. Three independent biological replicates. (B) The presence of ChemR23 (green) on CCs and oocyte was analyzed by fluorescence microscope. The nuclei of CCs and oocyte were stained with DAPI (blue). The outs... View More
Product Details
PA5-50932
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from the Internal region of human ChemR23 (aa 221-270).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636380
Product Specific Information
CHEMR23 / CMKLR1 Polyclonal Antibody detects endogenous levels of CHEMR23 / CMKLR1 protein.
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: chemerin receptor; Chemerin-like receptor 1; chemokine receptor-like 1; Chemokine-like receptor 1; G-protein coupled chemoattractant-like receptor; G-protein coupled receptor 27; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; orphan G-protein coupled receptor, Dez; resolvin E1 receptor
Gene Aliases: CHEMERINR; CHEMR23; CMKLR1; DEZ; Gpcr27; mcmklr1; RVER1
UniProt ID: (Human) Q99788, (Mouse) P97468, (Rat) O35786
Entrez Gene ID: (Human) 1240, (Mouse) 14747, (Rat) 60669
chemotaxis
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of macrophage chemotaxis
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-12 production
positive regulation of fat cell differentiation
regulation of calcium-mediated signaling
chemokine-mediated signaling pathway
skeletal system development
immune response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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