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Invitrogen
CML66 Polyclonal Antibody
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Product Details
PA5-54716
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CML66. Recombinant protein control fragment (Product #RP-93769).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2639925
Product Specific Information
Immunogen sequence: IKKNEGLTWP ELVIGDKQGE LIRDSAQCAA IAERLMHLTS EELNPNPDKE KPPCNAQELE ECDIFFEESS SLCRFDGNTL KTTHVVNLGS NQYL
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 96%.
Target Information
CML66, also known as TSGA10 (Testis Specific Gene A10), is a gene located on chromosome 8q23 that encodes a broadly immunogenic tumor antigen. The gene is expressed in various leukemias and solid tumors but has restricted expression in normal tissues, being predominantly found in the testis and heart. The physiological function of CML66 remains unclear. However, its immunogenic properties, including the ability to elicit strong humoral immune responses, make it a potential target for cancer immunotherapy. Studies have identified cytotoxic T lymphocyte (CTL) epitopes derived from CML66, suggesting that TSGA10-targeted therapies could be feasible. Moreover, research into the gene has revealed the existence of different isoforms, such as CML66-L (long) and CML66-S (short), which may have distinct roles in tumorigenesis and immune response modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chronic myelogenous leukemia tumor antigen 66; NudC domain-containing protein 1; NUDCD1; Tumor antigen CML66
Gene Aliases: CML66; NUDCD1; OVA66; RGD1310624
UniProt ID: (Human) Q96RS6
Entrez Gene ID: (Human) 84955, (Rat) 362906
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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