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Alomone Labs, LTD
CNIH2/3 (extracellular) Polyclonal Antibody
FIGURE: 1 / 1
CNIH2/3 (extracellular) Antibody (AGC-047-200UL) in WB
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4)brain lysates: - 1,2. Anti-CNIH2/3 (extracellular) Antibody (#AGC-047), (1:200).3,4. Anti-CNIH2/3 (extracellular) Antibody , preincubated with CNIH2/3 (extracellular) Blocking Peptide (#BLP-GC047).
Product Details
AGC-047-200UL
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RARERLKNIERIC, corresponding to amino acid residues 49-61 of rat CNIH2, Extracellular loop
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Cornichon homologs (CNIHs) are a family of AMPA-type glutamate receptor (AMPAR) auxiliary subunits that modulate AMPAR ion channel function and trafficking. Cornichon 2 and 3 (CNIH2/3) are responsible for controlling the export of AMPARs from the endoplasmic reticulum and associate with synaptic AMPARs to modulate channel kinetics. CNIHs are small proteins with three transmembrane domains that directly binds to AMPARs. Overexpression CNIHs and AMPA receptors causes their localization to the Golgi apparatus. CNIH and TARP both compete for the binding to AMPAR subunits GluA2, GluA3, and GluA4 subunits, suggesting both proteins bind to the same site. CNIH2/3 binding to AMPARs is dependent on AMPAR subunit composition and TARPs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CNIH-2; CNIH-3; cornichon 3; Cornichon family AMPA receptor auxiliary protein 2; Cornichon family AMPA receptor auxiliary protein 3; cornichon homolog 2; cornichon homolog 3; Cornichon-like protein; Protein cornichon homolog 2; Protein cornichon homolog 3
Gene Aliases: 2900075G08Rik; CNIH-2; CNIH-3; Cnih2; Cnih3; Cnil; RGD1304930
UniProt ID: (Rat) Q5BJU5, (Mouse) O35089, (Rat) D0Q0Y7, (Mouse) Q6ZWS4
Entrez Gene ID: (Rat) 361705, (Mouse) 12794, (Rat) 690252, (Mouse) 72978
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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