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This gene encodes a multidomain protein that functions as a scaffold protein to mediate the mitogen-activated protein kinase pathways downstream from Ras. This gene product is induced by vitamin D and inhibits apoptosis in certain cancer cells. It may also play a role in ternary complex assembly of synaptic proteins at the postsynaptic membrane and coupling of signal transduction to membrane/cytoskeletal remodeling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CNK homolog protein 2; CNK2; CNK2B; Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; connector enhancer of KSR2; KSR2B; Maguin; maguin-1; maguin-2; Membrane-associated guanylate kinase-interacting protein
Gene Aliases: C030004A01; CNK2; CNKSR2; KIAA0902; KSR2; MAGUIN; mKIAA0902
UniProt ID: (Human) Q8WXI2, (Rat) Q9Z1T4, (Mouse) Q80YA9
Entrez Gene ID: (Human) 22866, (Rat) 59322, (Mouse) 245684
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