Proteintech

CNOT10 Polyclonal Antibody

CNOT10 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

CNOT10 Antibody (15938-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CNOT10 antibody 15938-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CNOT10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CNOT10 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15938-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CNOT10 Fusion Protein Ag7654 (568-717 aa encoded by BC002928)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NPENVTDVS LGISSNEQDQ GSDKGENEAM ESSGKRAPQC YPSSVNSART VMLFNLGSAY CLRSEYDKAR KCLHQAASMI HPKEVPPEAI LLAVYLELQN GNTQLALQII KRNQLLPAVK THSEVRKKPV FQPVHPIQPI QMSAFTTVQR K (568-717 aa encoded by BC002928)

Target Information

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions.

Cell reports

Mauxion F,Basquin J,Ozgur S,Rame M,Albrecht J,Schäfer I,Séraphin B,Conti E

Tue Jan 31 00:00:00 UTC 2023

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Nature cancer

Zhang T,Sun L,Hao Y,Suo C,Shen S,Wei H,Ma W,Zhang P,Wang T,Gu X,Li ST,Chen Z,Yan R,Zhang Y,Cai Y,Zhou R,Jia W,Huang F,Gao P,Zhang H

Sat Jan 01 00:00:00 UTC 2022

Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation.

Genome biology

Poetz F,Lebedeva S,Schott J,Lindner D,Ohler U,Stoecklin G

Mon Sep 12 00:00:00 UTC 2022

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation.

Nature communications

Poetz F,Corbo J,Levdansky Y,Spiegelhalter A,Lindner D,Magg V,Lebedeva S,Schweiggert J,Schott J,Valkov E,Stoecklin G

Thu Dec 09 00:00:00 UTC 2021

Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

Nucleic acids research

Chapat C,Chettab K,Simonet P,Wang P,De La Grange P,Le Romancer M,Corbo L

Mon Aug 21 00:00:00 UTC 2017

Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

Nucleic acids research

Chapat C,Chettab K,Simonet P,Wang P,De La Grange P,Le Romancer M,Corbo L

Mon Aug 21 00:00:00 UTC 2017

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.

Nucleic acids research

Färber V,Erben E,Sharma S,Stoecklin G,Clayton C

Tue Jan 01 00:00:00 UTC 2013

Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs.

Nucleic acids research

Färber V,Erben E,Sharma S,Stoecklin G,Clayton C

Tue Jan 01 00:00:00 UTC 2013

C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.

RNA biology

Mauxion F,Prève B,Séraphin B

Fri Feb 01 00:00:00 UTC 2013

C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.

RNA biology

Mauxion F,Prève B,Séraphin B

Fri Feb 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: CCR4-NOT transcription complex subunit 10; CCR4-NOT transcription complex, subunit 10; FLJ12890; FLJ13165

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Gene Aliases: 2600001P13Rik; CNOT10

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UniProt ID: (Human) Q9H9A5, (Mouse) Q8BH15, (Rat) Q5XIA4

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Entrez Gene ID: (Human) 25904, (Mouse) 78893, (Rat) 316034

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Function(s)

protein binding molecular_function

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated regulation of translation biological_process gene silencing by RNA nuclear-transcribed mRNA poly(A) tail shortening DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CNOT10 Polyclonal Antibody

CNOT10 Antibody (15938-1-AP) in ICC/IF

Product Details

15938-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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