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Product Details
BS-9383R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human CNOT2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CCR4-NOT Transcription Complex 2 (CNOT2) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT2 is required for the CCR4-NOT complex structural integrity. It can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. CNOT2 is involved in the maintenance of embryonic stem (ES) cell identity. (UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; negative regulator of transcription 2
Gene Aliases: 2600016M12Rik; 2810470K03Rik; AA537049; AA959607; AW557563; C79650; CDC36; CNOT2; HSPC131; MSTP046; NOT2; NOT2H
UniProt ID: (Human) Q9NZN8, (Mouse) Q8C5L3
Entrez Gene ID: (Human) 4848, (Rat) 299805, (Mouse) 72068
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
positive regulation of cytoplasmic mRNA processing body assembly
negative regulation of intracellular estrogen receptor signaling pathway
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of stem cell population maintenance
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of translation
multicellular organism development
gene silencing by RNA
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
negative regulation of translation
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