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Proteintech
CNOT3 Polyclonal Antibody
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Product Details
11135-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CNOT3 Fusion Protein Ag1587 (449-753 aa encoded by BC016474)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NASSQALGP PSGPHNPPPS TSKEPSAAAP TGAGGVAPGS GNNSGGPSLL VPLPVNPPSS PTPSFSDAKA AGALLNGPPQ FSTAPEIKAP EPLSSLKSMA ERAAISSGIE DPVPTLHLTE RDIILSSTSA PPASAQPPLQ LSEVNIPLSL GVCPLGPVPL TKEQLYQQAM EEAAWHHMPH PSDSERIRQY LPRNPCPTPP YHHQMPPPHS DTVEFYQRLS TETLFFIFYY LEGTKAQYLA AKALKKQSWR FHTKYMMWFQ RHEEPKTITD EFEQGTYIYF DYEKWGQRKK EGFTFEYRYL EDRDLQ (449-753 aa encoded by BC016474)
Target Information
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CCR4-associated factor 3; CCR4-NOT transcription complex subunit 3; CCR4-NOT transcription complex, subunit 3; Leukocyte receptor cluster member 2; NOT3 (negative regulator of transcription 3, yeast) homolog
Gene Aliases: A930039N10Rik; CNOT3; KIAA0691; LENG2; NOT3; NOT3H
UniProt ID: (Human) O75175, (Mouse) Q8K0V4
Entrez Gene ID: (Human) 4849, (Mouse) 232791, (Rat) 308311
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
negative regulation of translation
gene silencing by RNA
regulation of stem cell population maintenance
regulation of translation
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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