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Proteintech
CNOT4 Polyclonal Antibody
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Product Details
12564-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CNOT4 Fusion Protein Ag3163 (273-572 aa encoded by BC035590)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: IDKPSDSLS IGNGDNSQQI SNSDTPSPPP GLSKSNPVIP ISSSNHSARS PFEGAVTESQ SLFSDIFRHP NPIPSGLPPF PSSPQTSSDW PTAPEPQSLF TSETIPVSSS TDWQAAFGFG SSKQPEDDLG FDPFDVTRKA LADLIEKELS VQDQPSLSPT SLQNSSSHTT TAKGPGSGFL HPAAATNANS LNSTFSVLPQ RFPQFQQHRA VYNSFSFPGQ AARYPWMAFP RNSIMHLNHT ANPTSNSNFL DLNLPPQHNT GLGGIPVAGE EEVKVSTMPL STSSHSLQQG QQPTSLHTTV A (273-572 aa encoded by BC035590)
Target Information
CNOT4 is a 575 amino acid protein with E3 ubiquitin ligase activity, mainly involved in protein modification and protein ubiquitination. It contains a ring type zinc finger domain of the C4C4 type, an RNA recognition motif and a bipartite nuclear localization signal.Studies show that CNOT4 is a component of the CCR4-NOT (CAF1) core complex that functions as general transcription regulation complex and has both a positive as well as a negative effect on the transcription of multiple functionally unrelated genes, thus controls gene expression. CNOT4 interacts with CNOT1 via C-terminus and with E2 ubiquitin ligases via C4C4 RING domain. Reports suggest that CNOT4 gets phosphorylated in response to DNA damage on consensus sites recognized by ATM and ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CCR4-NOT transcription complex, subunit 4; E3 ubiquitin-protein ligase CNOT4; negative regulator of transcription 4; NOT4 (negative regulator of transcription 4, yeast) homolog; Potential transcriptional repressor NOT4Hp; RING-type E3 ubiquitin transferase CNOT4; transcriptional repressor NOT4Hp
Gene Aliases: CLONE243; CNOT4; NOT4; NOT4H; Not4hp
UniProt ID: (Human) O95628, (Mouse) Q8BT14
Entrez Gene ID: (Human) 4850, (Rat) 312227, (Mouse) 53621
nucleotide binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
poly(A) RNA binding
nucleic acid binding
RNA binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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